Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Shalini T. Low-Nam"'
Autor:
Darren B. McAffee, Mark K. O’Dair, Jenny J. Lin, Shalini T. Low-Nam, Kiera B. Wilhelm, Sungi Kim, Shumpei Morita, Jay T. Groves
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The linker for activation of T cells (LAT) protein is involved in the activation of T cells. Here the authors discover micron scale LAT condensation events downstream of singly bound T-cell receptors during T cell activation and characterise how LAT
Externí odkaz:
https://doaj.org/article/82822abc182e454491b09902b4a15ff6
Autor:
Brandon L. Scott, Kem A. Sochacki, Shalini T. Low-Nam, Elizabeth M. Bailey, QuocAhn Luu, Amy Hor, Andrea M. Dickey, Steve Smith, Jason G. Kerkvliet, Justin W. Taraska, Adam D. Hoppe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Two distinct and opposing models for clathrin-mediated endocytosis have been inferred from EM and structural biology data. Here the authors develop an optical method to directly visualize membrane-bending dynamics and show that coat assembly accommod
Externí odkaz:
https://doaj.org/article/2fe8db89130d4f17aa027a673b9544f1
Autor:
Young Kwang Lee, Shalini T. Low-Nam, Jean K. Chung, Scott D. Hansen, Hiu Yue Monatrice Lam, Steven Alvarez, Jay T. Groves
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The guanine nucleotide exchange factor SOS is a critical intermediary that transduces receptor tyrosine kinase stimulation into Ras activation. Here the authors develop a single molecule assay in which SOS is captured from raw lysates using Ras-funct
Externí odkaz:
https://doaj.org/article/2e94ef8418fb45d8a6f011beb41476a4
Autor:
Ryan W. Curtis, Kevin L. Scrudders, James R. W. Ulcickas, Garth J. Simpson, Shalini T. Low-Nam, Jean Chmielewski
Publikováno v:
ACS Biomater Sci Eng
The use of biomaterials for the inclusion and stabilization of biopolymers is an ongoing challenge. Herein, we disclose three-dimensional (3D) coiled-coil peptide crystals with metal ions that include and overgrow His-tagged fluorescent proteins with
Membrane Association Transforms an Inert Anti-TCRβ Fab’ Ligand into a Potent T Cell Receptor Agonist
Autor:
Nicole C. Fay, Jenny J. Lin, Michael P. Coyle, Kiera B. Wilhelm, Katherine N. Alfieri, Shalini T. Low-Nam, Jay T. Groves, Geoff P. O’Donoghue
Publikováno v:
Biophysical Journal. 118:2879-2893
The natural peptide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells at single-molecule levels when membrane-associated. This distinctive feature stems from the mec
Autor:
Darren B. McAffee, Mark K. O’Dair, Jenny J. Lin, Shalini T. Low-Nam, Kiera B. Wilhelm, Sungi Kim, Shumpei Morita, Jay T. Groves
LAT assembly into a two-dimensional protein condensate is a prominent feature of antigen discrimination by T cells. Here, we use single-molecule imaging techniques to resolve the spatial position and temporal duration of each pMHC:TCR molecular bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200a2f90fa627c610edc935830b51b1b
https://doi.org/10.1101/2021.12.16.472676
https://doi.org/10.1101/2021.12.16.472676
Autor:
Troy C Lund, Amanda J Kobs, Ashley Kramer, Mick Nyquist, Marcos T Kuroki, John Osborn, Diane S Lidke, Shalini T Low-Nam, Bruce R Blazar, Jakub Tolar
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58945 (2013)
The ability of cells to detect changes in the microenvironment is important in cell signaling and responsiveness to environmental fluctuations. Our interest is in understanding how human bone marrow stromal-derived cells (MSC) and their relatives, va
Externí odkaz:
https://doaj.org/article/d7fc5c7d85da45d1a727b6acf791b772
Autor:
Jean K. Chung, Jay T. Groves, Young Kwang Lee, Hiu Yue Monatrice Lam, Scott D. Hansen, Steven Alvarez, Shalini T. Low-Nam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a critical role in signal transduction by activating Ras. Here we introduce a single-molecule assay in which individual SOS molecules are captured from raw cell lysate using Ra
Autor:
Jay T. Groves, Scott D. Hansen, Jenny J. Lin, Darren McAffee, Steven Alvarez, Shalini T. Low-Nam
Publikováno v:
Biophysical Journal. 118:247a-248a
Autor:
Kem A. Sochacki, Andrea M. Dickey, Adam D. Hoppe, Amy Hor, Shalini T. Low-Nam, Jason G. Kerkvliet, QuocAhn Luu, Elizabeth M. Bailey, Brandon L. Scott, Steve Smith, Justin W. Taraska
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small regions of the cell surface into spherical vesicles. The key mechanistic question of how coat assembly produces membrane curvature has been studied with molecular and