Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shalini, Das Gupta"'
Autor:
Noora Puhakka, Shalini Das Gupta, Sara Leskinen, Mette Heiskanen, Janika N?ttinen, Ulla Aapola, Hannu Uusitalo, Asla Pitk?nen
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 359-366 (2023)
Traumatic brain injury (TBI) damages the glymphatic-lymphatic system. We hypothesized that brain injury associated with trauma results in the enrichment of brain-relevant proteins in deep cervical lymph nodes (DCLNs), the end station of meningeal lym
Externí odkaz:
https://doaj.org/article/bb3e46d14d1d4ef3a2c4d7681f7e74e2
Autor:
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2823 (2023)
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to the development of anti-epileptogenic treatments. Previous stud
Externí odkaz:
https://doaj.org/article/7cb1f8cc01744e48a0dd32c913752564
Autor:
Mette Heiskanen, Olli Jääskeläinen, Eppu Manninen, Shalini Das Gupta, Pedro Andrade, Robert Ciszek, Olli Gröhn, Sanna-Kaisa Herukka, Noora Puhakka, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15208 (2022)
Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for traumatic brain injury (TBI) and as a prognostic biomarker for somatomotor recovery, cognitive decline, and epileptogenesis. Rats with severe TBI induced by la
Externí odkaz:
https://doaj.org/article/49991ee49d01431aad7523ce87096785
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 136 (2022)
Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injur
Externí odkaz:
https://doaj.org/article/30ccca4e4d274c79ac4586cd391d04b9
Autor:
Jenni Karttunen, Mette Heiskanen, Vicente Navarro-Ferrandis, Shalini Das Gupta, Anssi Lipponen, Noora Puhakka, Kirsi Rilla, Arto Koistinen, Asla Pitkänen
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
The microRNA (miRNA) cargo contained in plasma extracellular vesicles (EVs) offers a relatively little explored source of biomarkers for brain diseases that can be obtained noninvasively. Methods to isolate EVs from plasma, however, are still being d
Externí odkaz:
https://doaj.org/article/714647fa127c45f289b2991561f1709d
Autor:
Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen, Teresa Ravizza, Annamaria Vezzani, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10555 (2021)
We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug N-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the
Externí odkaz:
https://doaj.org/article/b998370c5ed947969d9f9c88922b1f47
Autor:
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1563 (2021)
Noninvasive, affordable circulating biomarkers for difficult-to-diagnose mild traumatic brain injury (mTBI) are an unmet medical need. Although blood microRNA (miRNA) levels are reportedly altered after traumatic brain injury (TBI), their diagnostic
Externí odkaz:
https://doaj.org/article/0a5b373e9b214357bb68bccfffb13c93
Publikováno v:
Biomedicines; Volume 10; Issue 1; Pages: 136
Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injur
Publikováno v:
Neuroscience. 433:21-35
Mechanisms initiated by traumatic brain injury (TBI), leading to the development of progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed role in orchestrating the post-injury aftermath as a single miRNA can control t
Publikováno v:
Biomedicines
Biomedicines, Vol 10, Iss 136, p 136 (2022)
Biomedicines, Vol 10, Iss 136, p 136 (2022)
Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injur