Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shaline V Fazal"'
Autor:
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Publikováno v:
eLife, Vol 10 (2021)
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon g
Externí odkaz:
https://doaj.org/article/71cf5cebbc4d40f8b6b3a29c0b196abc
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1
Externí odkaz:
https://doaj.org/article/11212149181f416b8c3e590d274fb1a6
Autor:
Jose A. Gomez-Sanchez, Nikiben Patel, Fernanda Martirena, Shaline V. Fazal, Clara Mutschler, Hugo Cabedo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2996 (2022)
The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the central nervous system (CNS), a phenomenon that is impaired during ageing. The ability of PNS axons to regenerate after injury is due to Schwann cells (SC
Externí odkaz:
https://doaj.org/article/6be68458c0d241ac8dd2fc67060c5e50
Autor:
Clara Mutschler, Shaline V. Fazal, Nathalie Schumacher, Andrea Loreto, Michael P. Coleman, Peter Arthur-Farraj
Myelinating Schwann cell (SC)– dorsal root ganglion (DRG) neuron cocultures have been an important technique over the last four decades in understanding cell-cell signalling and interactions during peripheral nervous system (PNS) myelination, injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f617941717bc17e1c956f2e4f3935571
https://doi.org/10.1101/2023.05.19.541371
https://doi.org/10.1101/2023.05.19.541371
Autor:
Peter J. Arthur-Farraj, Claire C. Morgan, Martyna Adamowicz, Jose A. Gomez-Sanchez, Shaline V. Fazal, Anthony Beucher, Bonnie Razzaghi, Rhona Mirsky, Kristjan R. Jessen, Timothy J. Aitman
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2719-2734 (2017)
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methy
Externí odkaz:
https://doaj.org/article/b1df5bc580954457aa1f44a8b2ac5ad5
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J.M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
SARM1 is a central regulator of programmed axon death and is required to initiate axon self-destruction after traumatic and toxic insults to the nervous system. Abnormal activation of this axon degeneration pathway is increasingly recognized as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb1fe267175f2f740304601c4e3b108
https://doi.org/10.1101/2022.12.08.519209
https://doi.org/10.1101/2022.12.08.519209
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Autor:
Shaline V. Fazal, Georg W. Otto, Peter Arthur-Farraj, Sergio Velasco-Aviles, Jose A. Gomez-Sanchez, Cristina Benito, Mark Turmaine, Rhona Mirsky, Liam Yn Wong, Kirolos Michael, Hugo Cabedo, Alastair M. Kilpatrick, Tessa Gordon, Kristjan R. Jessen, Ki H. Ma, Laura Wagstaff, John Svaren
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
eLife
eLife, Vol 10 (2021)
Wagstaff, L J, Gomez-Sanchez, J A, Fazal, S V, Otto, G W, Kilpatrick, A M, Michael, K, Wong, L YN, Ma, K H, Turmaine, M, Svaren, J, Gordon, T, Arthur-Farraj, P, Velasco-Aviles, S, Cabedo, H, Benito, C, Mirsky, R & Jessen, K R 2021, ' Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.62232
instname
eLife
eLife, Vol 10 (2021)
Wagstaff, L J, Gomez-Sanchez, J A, Fazal, S V, Otto, G W, Kilpatrick, A M, Michael, K, Wong, L YN, Ma, K H, Turmaine, M, Svaren, J, Gordon, T, Arthur-Farraj, P, Velasco-Aviles, S, Cabedo, H, Benito, C, Mirsky, R & Jessen, K R 2021, ' Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.62232
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon g
Autor:
Peter Arthur-Farraj, Laura J. Wagstaff, Georg W. Otto, Tessa Gordon, Cristina Benito, Kirolos Michael, Alastair M. Kilpatrick, Liam Yn Wong, Sergio Velasco-Aviles, Ki H. Ma, Mark Turmaine, Jose A. Gomez-Sanchez, Shaline V. Fazal, Kristjan R. Jessen, Hugo Cabedo, Rhona Mirsky, John Svaren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94bdb847e4b07b528e9d6330e68e3aac
https://doi.org/10.7554/elife.62232.sa2
https://doi.org/10.7554/elife.62232.sa2
Autor:
Jose A, Gomez-Sanchez, Kjara S, Pilch, Milou, van der Lans, Shaline V, Fazal, Cristina, Benito, Laura J, Wagstaff, Rhona, Mirsky, Kristjan R, Jessen
Publikováno v:
The Journal of Neuroscience
There is consensus that, distal to peripheral nerve injury, myelin and Remak cells reorganize to form cellular columns, Bungner's bands, which are indispensable for regeneration. However, knowledge of the structure of these regeneration tracks has no