Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shalina Taylor"'
Autor:
Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human P
Externí odkaz:
https://doaj.org/article/77e16fe3567e4a3f89266732e6c31cf1
Autor:
Jan-Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R. Mumbach, Fan Zhang, Ramesh V. Nair, Joseph Nasser, Daniel H. Mai, Shalina Taylor, Lingli Wang, Ross J. Metzger, Howard Y. Chang, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors studied pulmonary arterial endothelial cells (PAEC) under laminar shear stress and show that this physiologic condition markedly changes chromatin accessibility at regulatory regions, when compared to cells grown in a static state. T
Externí odkaz:
https://doaj.org/article/dd0de669b721470b8265ca8d188386af
Autor:
Shoichiro Otsuki, Toshie Saito, Shalina Taylor, Dan Li, Jan-Renier Moonen, David P. Marciano, Rebecca L. Harper, Aiqin Cao, Lingli Wang, Maria E. Ariza, Marlene Rabinovitch
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hy
Externí odkaz:
https://doaj.org/article/cef82f1c90464af295d891c0012529c9
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries. The vasculopathy is accompanied by perivascular inflammation and in
Externí odkaz:
https://doaj.org/article/e8f7b2c39c284c54ae03411251b7e7b6
Autor:
Lingli Wang, Jan-Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pin-I. Chen, Mingxia Gu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, Yu-Mee Kim, Kryn Stankunas, Marlene Rabinovitch
Publikováno v:
Circulation Research. 132:545-564
Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PA
Autor:
Shalina Taylor, Sarasa Isobe, Aiqin Cao, Kévin Contrepois, Bérénice A. Benayoun, Lihua Jiang, Lingli Wang, Stavros Melemenidis, Mehmet O. Ozen, Shoichiro Otsuki, Tsutomu Shinohara, Andrew J. Sweatt, Jordan Kaplan, Jan-Renier Moonen, David P. Marciano, Mingxia Gu, Kazuya Miyagawa, Brandon Hayes, Raymond G. Sierra, Christopher J. Kupitz, Patricia A. Del Rosario, Andrew Hsi, A. A. Roger Thompson, Maria E. Ariza, Utkan Demirci, Roham T. Zamanian, Francois Haddad, Mark R. Nicolls, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 206:1019-1034
Rationale: The role of neutrophils and their extracellular vesicles (EVs) in the pathogenesis of pulmonary arterial hypertension is unclear. Objectives: Relate functional abnormalities in pulmonary arterial hypertension neutrophils and their EVs to m
Autor:
Andrew J. Sweatt, Olaf Mercier, Alokkumar Jha, Roham T. Zamanian, Anton Vonk Noordegraaf, André Y. Denault, Jennifer Arthur Ataam, Myriam Amsallem, Francois Haddad, Tatiana Kouznetsova, Roberto Bernardo, Shalina Taylor, Kévin Contrepois
Publikováno v:
Haddad, F, Contrepois, K, Amsallem, M, Denault, A Y, Bernardo, R J, Jha, A, Taylor, S, Arthur Ataam, J, Mercier, O, Kuznetsova, T, Vonk Noordegraaf, A, Zamanian, R T & Sweatt, A J 2022, ' The Right Heart Network and Risk Stratification in Pulmonary Arterial Hypertension ', Chest, vol. 161, no. 5, pp. 1347-1359 . https://doi.org/10.1016/j.chest.2021.10.045
Chest, 161(5), 1347-1359. American College of Chest Physicians
Chest, 161(5), 1347-1359. American College of Chest Physicians
BACKGROUND: Prognosis in pulmonary arterial hypertension (PAH) is closely related to indexes of right ventricular function. A better understanding of their relationship may provide important implications for risk stratification in PAH. RESEARCH QUEST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebb202aef33461832d996c3bf31ac11
https://research.vumc.nl/en/publications/82729c81-5283-4ab2-aa04-268f2fb7d297
https://research.vumc.nl/en/publications/82729c81-5283-4ab2-aa04-268f2fb7d297
Autor:
Nirmal K Sampathkumar, Minhoo Kim, Juan I. Bravo, Bérénice A. Benayoun, Ryan J Lu, Kévin Contrepois, Mathew Ellenberger, Shalina Taylor
Publikováno v:
Nat Aging
Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus the impact of organismal aging on neutrophil biology, especially as a function
Autor:
Marlene Rabinovitch, Toshie Saito, Maria Eugenia Ariza, Shoichiro Otsuki, Jan-Renier A. J. Moonen, Lingli Wang, Aiqin Cao, David Marciano, Dan Li, Shalina Taylor, Rebecca L. Harper
Publikováno v:
JCI Insight
We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hy
Autor:
Marlene Rabinovitch, Angela J. Rogers, Madeline J. Lee, Nancy Q. Zhao, Samuel Yang, Catherine A. Blish, Bei Wei, Benjamin Parks, Ruoxi Pi, Ruth O'Hara, Winston R. Becker, Euan A. Ashley, Kari C. Nadeau, Giovanny J Martínez-Colón, Susan Holmes, Shalina Taylor, Aaron J. Wilk, Thanmayi Ranganath, David Jimenez-Morales, William J. Greenleaf, Andra L. Blomkalns, Stanford Covid Biobank
Publikováno v:
The Journal of Experimental Medicine
Single-cell profiling demonstrates multifarious dysregulation of innate immune phenotype associated with COVID-19 severity. Severe COVID-19 is associated with hyperactivation of neutrophils and NK cells, while monocytes take on tolerogenic phenotypes