Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Shalina Mahajan-Miklos"'
1
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
Autor: Marco Kessler, Etchell A. Cordero, Robert W. Busby, Wilmin Bartolini, Gerhard Hannig, Mark G. Currie, Caroline B. Kurtz, Jenny Tobin, Alexander P. Bryant, Shalina Mahajan-Miklos, Robert Solinga, Christine M. Pierce, Mitchell B. Cohen
Publikováno v: Life Sciences. 86:760-765
Aims Linaclotide is an orally administered 14-amino acid peptide being developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. We determined the stability of linaclotide in the intestine, mea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d74fdae2ce259baa4e2118fc30a5d99
https://doi.org/10.1016/j.lfs.2010.03.015
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2
Drosophila Quail, a villin-related protein, bundles actin filaments in apoptotic nurse cells
Autor: Shalina Mahajan-Miklos, Nina Matova, Mark S. Mooseker, Lynn Cooley
Publikováno v: Development. 126:5645-5657
Drosophila Quail protein is required for the completion of fast cytoplasm transport from nurse cells to the oocyte, an event critical for the production of viable oocytes. The abundant network of cytoplasmic filamentous actin, established at the onse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f05fc8e0c3ae75b7da43c0a59b55bc6
https://doi.org/10.1242/dev.126.24.5645
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3
Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail
Autor: Lynn Cooley, Brenda A. Knowles, Kelly Cant, Matthew B. Heintzelman, Shalina Mahajan-Miklos
Publikováno v: Journal of Cell Science. 111:213-221
Actin bundle assembly in specialized structures such as microvilli on intestinal epithelia and Drosophila bristles requires two actin bundling proteins. In these systems, the distinct biochemical properties and temporal localization of actin bundling
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba4e0196c4c1a17d6348399d32b3fd6
https://doi.org/10.1242/jcs.111.2.213
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4
The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis
Autor: Shalina Mahajan-Miklos, Lynn Cooley
Publikováno v: Cell. 78:291-301
Mutations in the Drosophila quail gene result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis. Nurse cells from quail mutant egg chambers fail to assemble cytoplasmic actin fil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eedac895f35f3f38fb04cbf2b047ab8
https://doi.org/10.1016/0092-8674(94)90298-4
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5
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
Autor: Etchell A. Cordero, Robert Solinga, Mark G. Currie, Robert W. Busby, Caroline B. Kurtz, Marco Kessler, Li Jing Sun, Shalina Mahajan-Miklos, Wilmin Bartolini, Alexander P. Bryant, Gerhard Hannig, Christine M. Pierce, Jenny Tobin
Publikováno v: European journal of pharmacology. 649(1-3)
Linaclotide is a first-in-class, orally administered 14-amino acid peptide that is in development for the treatment of irritable bowel syndrome with constipation and chronic constipation. We have characterized the solution structure of linaclotide, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4926aec843727e758afb1ae8d2e73c4
https://pubmed.ncbi.nlm.nih.gov/20863829
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