Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shalia S Shabbir"'
Autor:
Fabrizio Nerozzi, Shalia S Shabbir, Paul G. Wyatt, Mamta Patel, Michael Allen, Josie Chilcott, Christopher J. Gardner, Marion J. Perren, Jackie E. Mordaunt, Livermore David, Gordon G. Weingarten, Ping Zhou, Patrick M. Woollard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1405-1411
The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1b65e9e762608b3da232e63c0d7e45
https://doi.org/10.1016/s0960-894x(02)00160-9
https://doi.org/10.1016/s0960-894x(02)00160-9
Autor:
Alan D. Borthwick, Dave E. Davies, Anne M. Exall, Richard J. D. Hatley, Jennifer A. Hughes, Wendy R. Irving, David G. Livermore, Steve L. Sollis, Fabrizio Nerozzi, Klara L. Valko, Michael J. Allen, Marion Perren, Shalia S. Shabbir, Patrick M. Woollard, Mark A. Price
Publikováno v:
Journal of medicinal chemistry. 49(14)
A short, efficient, and highly stereoselective synthesis of a series of (3R,6R,7R)-2,5-diketopiperazine oxytocin antagonists and their pharmacokinetics in rat and dog is described. Prediction of the estimated human oral absorption (EHOA) using measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9f99084e0ca4f2c727fbd23a0eaf80
https://pubmed.ncbi.nlm.nih.gov/16821776
https://pubmed.ncbi.nlm.nih.gov/16821776
Autor:
Marion J. Perren, Michael Allen, Patrick M. Woollard, Alan D. Borthwick, Paul G. Wyatt, Anne M. Exall, Dave E. Davies, Shalia S Shabbir, Steve L. Sollis, Fabrizio Nerozzi, Livermore David
Publikováno v:
Journal of medicinal chemistry. 48(22)
A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248d5a4c254ef2deee7352b8c047c9c7
https://pubmed.ncbi.nlm.nih.gov/16250654
https://pubmed.ncbi.nlm.nih.gov/16250654
Autor:
Wyatt PG; Department of Medicinal Chemistry, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Herts, UK., Allen MJ, Chilcott J, Gardner CJ, Livermore DG, Mordaunt JE, Nerozzi F, Patel M, Perren MJ, Weingarten GG, Shabbir S, Woollard PM, Zhou P
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 May 20; Vol. 12 (10), pp. 1405-11.