Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shalem Modi"'
Autor:
Nagendra Yaluri, Shalem Modi, Maykel López Rodríguez, Alena Stančáková, Johanna Kuusisto, Tarja Kokkola, Markku Laakso
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current stud
Externí odkaz:
https://doaj.org/article/516e1a0f32324b67a44de59cc9a622ae
Publikováno v:
Biochemical and Biophysical Research Communications. 480:194-200
Article
Simvastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used for the treatment of hypercholesterolemia. Recent data indicates that simvastatin increases the risk of new-onset diabetes by impairing both insulin secretio
Simvastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used for the treatment of hypercholesterolemia. Recent data indicates that simvastatin increases the risk of new-onset diabetes by impairing both insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2914cdfc787dab7c5a9ba30078e06344
https://doi.org/10.1016/j.bbrc.2016.10.026
https://doi.org/10.1016/j.bbrc.2016.10.026
Autor:
Markku Laakso, Shalem Modi, Johanna Kuusisto, Maykel López Rodríguez, Minna U. Kaikkonen, Lilian Fernandes Silva, Jagadish Vangipurapu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
The rs780094 single nucleotide polymorphism (SNP; C/T) of glucokinase regulatory protein gene (GCKR) is a regulatory genetic variant that has been associated with lactate levels in the fasting state. However, the association of this locus with lactat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ceb4665f047afb6333d3a672228692
https://doi.org/10.1038/s41598-018-34501-9
https://doi.org/10.1038/s41598-018-34501-9
Publikováno v:
Biochemical and biophysical research communications. 499(2)
Obesity is characterized by excess fat accumulation in white adipose tissue, which triggers chronic low-grade inflammation through secretion of pro-inflammatory factors by the enlarged adipocytes and infiltrated macrophages. This affects glucose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b761797f2716b009ada86f64c1c61367
https://pubmed.ncbi.nlm.nih.gov/29550483
https://pubmed.ncbi.nlm.nih.gov/29550483
Autor:
Shalem Modi, Henna Cederberg, Nagendra Yaluri, Johanna Kuusisto, Markku Laakso, Alena Stančáková
Publikováno v:
Diabetologia. 58:1109-1117
Aims/hypothesis The aim of this work was to investigate the mechanisms underlying the risk of type 2 diabetes associated with statin treatment in the population-based Metabolic Syndrome in Men (METSIM) cohort. Methods A total of 8,749 non-diabetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be60d3fb31cc670b4a06b93fe4b05781
https://doi.org/10.1007/s00125-015-3528-5
https://doi.org/10.1007/s00125-015-3528-5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including plant polyphenols such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f561f2e22123c75711a1a02da531a969
https://pubmed.ncbi.nlm.nih.gov/29242624
https://pubmed.ncbi.nlm.nih.gov/29242624
Autor:
Shalem Modi, Tarja Kokkola
Publikováno v:
F1000Research
GR24 is a synthetic strigolactone analog, demonstrated to regulate the development of plants and arbuscular mycorrhizal fungi. GR24 possesses anti-cancer and anti-apoptotic properties, enhances insulin sensitivity and mitochondrial biogenesis in skel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e9f7fecccf8767278c7d5780f0fda0
https://doi.org/10.12688/f1000research.16172.2
https://doi.org/10.12688/f1000research.16172.2
Autor:
Tarja Kokkola, Shalem Modi
Publikováno v:
F1000Research. 7:1459
GR24 is a synthetic strigolactone analog, demonstrated to regulate the development of plants and arbuscular mycorrhizal fungi. GR24 possesses anti-cancer and anti-apoptotic properties, enhances insulin sensitivity and mitochondrial biogenesis in skel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba048416df5127fbea10b822fc8913a
https://doi.org/10.12688/f1000research.16172.1
https://doi.org/10.12688/f1000research.16172.1
Autor:
Johanna Kuusisto, Maykel López Rodríguez, Tarja Kokkola, Alena Stančáková, Markku Laakso, Shalem Modi, Nagendra Yaluri
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90798ef97694837a855568240c19319
https://pubmed.ncbi.nlm.nih.gov/26561346
https://pubmed.ncbi.nlm.nih.gov/26561346
Autor:
Christoph H. Westphal, Marie Lagouge, Shalem Modi, Markku Vänttinen, Nagendra Yaluri, David A. Sinclair, Paula Itkonen, Jussi Pihlajamäki, Sakari Kainulainen, Markku Laakso, Peter J. Elliott, Johan Auwerx, Hiroyasu Yamamoto, Jarno Rutanen
Publikováno v:
Diabetes
OBJECTIVE Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e9ee6b50023a46d5d9ed1e60d23678
https://infoscience.epfl.ch/record/147169
https://infoscience.epfl.ch/record/147169
