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Samarium(II) iodide-mediated reductive annulations of ketones bearing a distal vinyl epoxide moiety.

Autor: Molander, Gary A., Shakya, Sagar R.

Publikováno v: Journal of Organic Chemistry; 8/23/96, Vol. 61 Issue 17, p5885, 10p, 5 Diagrams, 1 Chart

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

Autor: Tran TA; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Kramer B; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shin YJ; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Vallar P; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Boatman PD; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Zou N; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Sage CR; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Gharbaoui T; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Krishnan A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Pal B; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shakya SR; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Garrido Montalban A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Adams JW; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Ramirez J; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Behan DP; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shifrina A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Blackburn A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Leakakos T; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shi Y; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Morgan M; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Sadeque A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chen W; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Unett DJ; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Gaidarov I; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chen X; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chang S; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shu HH; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Tung SF; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Semple G; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 09; Vol. 60 (3), pp. 913-927. Date of Electronic Publication: 2017 Jan 19.