Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shakuntala, Tiwari"'
Autor:
Trousil, Sebastian, Chen, Shuang, Mu, Chan, Shaw, Fiona M., Yao, Zhan, Ran, Yuping, Shakuntala, Tiwari, Merghoub, Taha, Manstein, Dieter, Rosen, Neal, Cantley, Lewis C., Zippin, Jonathan H., Zheng, Bin
Publikováno v:
In Journal of Investigative Dermatology May 2017 137(5):1135-1143
Autor:
Taha Merghoub, Jedd D. Wolchok, Robert Olmsted, Maureen F. Maughan, Shakuntala Tiwari, Daniel Hirschhorn-Cymerman, Nicole Malandro, Sadna Budhu, Arvin Yang, Roberta Zappasodi, Francesca Avogadri
Induction of potent immune responses to self-antigens remains a major challenge in tumor immunology. We have shown that a vaccine based on alphavirus replicon particles (VRP) activates strong cellular and humoral immunity to tyrosinase-related protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f67f6f7cb77e9b9e6530278c4fd00f
https://doi.org/10.1158/2326-6066.c.6548896
https://doi.org/10.1158/2326-6066.c.6548896
Autor:
Taha Merghoub, Jedd D. Wolchok, Robert Olmsted, Maureen F. Maughan, Shakuntala Tiwari, Daniel Hirschhorn-Cymerman, Nicole Malandro, Sadna Budhu, Arvin Yang, Roberta Zappasodi, Francesca Avogadri
PDF file - 428K, Supplementary Figure S1. Depigmentation after combination therapy. Supplementary Figure S2. Tumor immune infiltrate after immunomodulation. Supplementary Figure S3. PD-1 expression on T cell subsets. Supplementary Figure S4. Effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d28c53d772054d517b83ba448696a1
https://doi.org/10.1158/2326-6066.22538794.v1
https://doi.org/10.1158/2326-6066.22538794.v1
Autor:
David B. Solit, Barry S. Taylor, Neal Rosen, Michael F. Berger, Taha Merghoub, Omar Abdel-Wahab, Agnes Viale, Shakuntala Tiwari, Alexander N. Shoushtari, Elena I. Gavrila, Hannah C. Wise, Wenhuo Hu, Yijun Gao, Zhan Yao, Abigail N. Poteshman, Clare A. Nimura, Moriah H. Nissan, Amber J. Kiliti, Alexis M. Jones, Alexander N. Gorelick, Sizhi P. Gao, Dong Xu, Ye Liu, Weiwei Han, Jianjiong Gao, Arijh Elzein, Matthew T. Chang, Brooke E. Sylvester, Aphrothiti J. Hanrahan
This supplementary data file contains 5 figures pertaining to the tumor distribution of MEK1 hotspot mutations, functional characterization of further MEK1/2 mutants with and without MEK or ERK inhibitor treatment, and the sequence paralogy alignment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a3e6dd9941792421f2a33dbc53984c
https://doi.org/10.1158/0008-5472.22426042.v1
https://doi.org/10.1158/0008-5472.22426042.v1
Autor:
David B. Solit, Barry S. Taylor, Neal Rosen, Michael F. Berger, Taha Merghoub, Omar Abdel-Wahab, Agnes Viale, Shakuntala Tiwari, Alexander N. Shoushtari, Elena I. Gavrila, Hannah C. Wise, Wenhuo Hu, Yijun Gao, Zhan Yao, Abigail N. Poteshman, Clare A. Nimura, Moriah H. Nissan, Amber J. Kiliti, Alexis M. Jones, Alexander N. Gorelick, Sizhi P. Gao, Dong Xu, Ye Liu, Weiwei Han, Jianjiong Gao, Arijh Elzein, Matthew T. Chang, Brooke E. Sylvester, Aphrothiti J. Hanrahan
Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdd1967470582e983e089d010a26b8b
https://doi.org/10.1158/0008-5472.c.6512212.v1
https://doi.org/10.1158/0008-5472.c.6512212.v1
Autor:
David B. Solit, Neal Rosen, Michael F. Berger, Nikolaus Schultz, Barry S. Taylor, Rona Yaeger, Paul B. Chapman, Antoni Ribas, Taha Merghoub, Zhan Yao, Aphrothiti J. Hanrahan, Li Kong, Shakuntala Tiwari, Cailian Liu, Helen Won, Ricardo Ramirez, Alexis M. Jones, Christine A. Pratilas, Moriah H. Nissan
Supplementary Figures S1-S8. Levels of RAS-GTP in melanoma cell lines (S1); Changes in pERK and cyclin D1 levels as function of time in cells treated with the MEK inhibitor PD0325901 (S2); Sk-Mel-113 (NF1 null) melanoma cells are resistant to AKT inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa01184a7e049a99c0f1035761f883e
https://doi.org/10.1158/0008-5472.22402383
https://doi.org/10.1158/0008-5472.22402383
Autor:
Matthew T. Chang, Dong Xu, Taha Merghoub, Yijun Gao, Michael F. Berger, Clare A. Nimura, Wenhuo Hu, Arijh Elzein, Omar Abdel-Wahab, David B. Solit, Alexander N. Shoushtari, Jianjiong Gao, Ye Liu, Zhan Yao, Brooke E. Sylvester, Weiwei Han, Moriah H. Nissan, Sizhi P. Gao, Hannah C. Wise, Agnes Viale, Aphrothiti J. Hanrahan, Amber J. Kiliti, Barry S. Taylor, Shakuntala Tiwari, Neal Rosen, Alexis Jones, Alexander N. Gorelick, Elena I. Gavrila, Abigail N. Poteshman
Publikováno v:
Cancer Res
Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f0dda7003ec100cb1745b83e8ff6ae
https://doi.org/10.1158/0008-5472.can-20-0865
https://doi.org/10.1158/0008-5472.can-20-0865
Autor:
Robert A. Olmsted, Arvin Yang, Maureen F. Maughan, Taha Merghoub, Nicole Malandro, Jedd D. Wolchok, Daniel Hirschhorn-Cymerman, Francesca Avogadri, Shakuntala Tiwari, Sadna Budhu, Roberta Zappasodi
Publikováno v:
Cancer immunology research. 2(5)
Induction of potent immune responses to self-antigens remains a major challenge in tumor immunology. We have shown that a vaccine based on alphavirus replicon particles (VRP) activates strong cellular and humoral immunity to tyrosinase-related protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c4441de66949f5ee40fbb2378b5b67
https://pubmed.ncbi.nlm.nih.gov/24795357
https://pubmed.ncbi.nlm.nih.gov/24795357
Autor:
Paul B. Chapman, Taha Merghoub, Alexis M. Jones, Michael F. Berger, Helen Won, Neal Rosen, Antoni Ribas, Li Kong, Barry S. Taylor, Nikolaus Schultz, Moriah H. Nissan, Rona Yaeger, Shakuntala Tiwari, Cailian Liu, Christine A. Pratilas, Zhan Yao, David B. Solit, Aphrothiti J. Hanrahan, Ricardo Ramirez
Publikováno v:
Cancer research, vol 74, iss 8
Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations that drive tumor progression in the remaining 30% are largely undefined. Vem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50397bb10399d16e9083e30bdd1bd93c
https://escholarship.org/uc/item/7wh2d1jg
https://escholarship.org/uc/item/7wh2d1jg
Autor:
Hanako Yamauchi, Shakuntala Tiwari, Francesca Orlandi, Antonio Concetti, Alan N. Houghton, Polly D. Gregor, Franco M. Venanzi, Jedd D. Wolchok, Larry Norton
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(20)
Purpose: HER2/neu is frequently overexpressed in breast cancer. In a mouse model, vaccination with HER2/neu DNA elicits antibodies that confer partial protection against tumor challenge. Experimental Design: To enhance antitumor immunity, we fused cD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f6262f2b7ed27846cd6edf6eab1b96
https://pubmed.ncbi.nlm.nih.gov/17947487
https://pubmed.ncbi.nlm.nih.gov/17947487