Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shakir Sarhan"'
Autor:
Claudia Neumann-Haefelin, Shakir Sarhan, Hans-Paul Juretschke, Juergen Kalisch, Petty Margaret, Joseph G Wettstein
Publikováno v:
European Journal of Pharmacology. 474:53-62
The neuroprotective activity of ACEA 1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione; licostinel), a selective antagonist at the strychnine-insensitive glycine site associated with the NMDA receptor complex, has been investigated in vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4921cc437249f5d17fb2608f2b198e
https://doi.org/10.1016/s0014-2999(03)02002-8
https://doi.org/10.1016/s0014-2999(03)02002-8
Publikováno v:
Neuroscience Letters. 347:147-150
The glycine site, N -methyl- d -aspartate antagonist 5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione (ACEA1021) was previously tested only in models of transient stroke with pre-treatment paradigms. We therefore tested whether it would protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3100e31db9c95455081068c6b1c7fd
https://doi.org/10.1016/s0304-3940(03)00693-1
https://doi.org/10.1016/s0304-3940(03)00693-1
Autor:
Nikolaus Seiler, Christine Grauffel, B. Knödgen, Paula M. Moran, Shakir Sarhan, M van den Buuse, S. Gobaille, J. Elands
Publikováno v:
Pharmacology Biochemistry and Behavior. 50:181-189
Acute and chronic administration of vigabatrin, a selective inactivator of GABA-T, suppresses haloperidol-induced dyskinesias at low doses without preventing the enhancement of striatal dopamine D2 receptor density or the development of vacuous chewi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149fcec81ac61eed9f2af2205092178c
https://doi.org/10.1016/0091-3057(94)00282-n
https://doi.org/10.1016/0091-3057(94)00282-n
Publikováno v:
Metabolic Brain Disease. 9:211-224
5-Fluoromethylornithine (5FMOrn) is a selective inactivator of ornithine aminotransferase. Administration of this compound to rodents causes a prominent increase of tissue ornithine concentrations, and prevents the neurological consequences of acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8bd2472b11f71eb0dab58a2f651bc8
https://doi.org/10.1007/bf01991195
https://doi.org/10.1007/bf01991195
Publikováno v:
Metabolic Brain Disease. 9:67-79
The protective effects of combinations of 5-fluoromethylornithine (5FMOrn), a selective inhibitor of ornithine aminotransferase, and of compounds known to antagonize ammonia toxicity, were studied in acute, lethal ammonia intoxication in mice. Two te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72810301900af9223ec4ebcb46c8db5
https://doi.org/10.1007/bf01996075
https://doi.org/10.1007/bf01996075
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 653:87-91
Orotic acid was separated from other urinary constituents by ion-pair formation with tetrabutylammonium, and isocratic elution from a reversed-phase column. Absorbance at 280 nm was recorded for quantitation. Owing to the better column characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e274782d64a618d4a63df94c47ca9070
https://doi.org/10.1016/0378-4347(93)e0409-j
https://doi.org/10.1016/0378-4347(93)e0409-j
Publikováno v:
Neurochemical Research. 18:539-549
Repeated administration of thioacetamide (TAA) to CD1 mice produced hepatic failure and biochemical and behavioral effects characteristic of hepatogenic encephalopathy (HE). The symptoms in mice resembled those previously observed in rats after simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cee57b25d2225e6c1817fde0f0930fc
https://doi.org/10.1007/bf00967259
https://doi.org/10.1007/bf00967259
Publikováno v:
Pharmacology & Toxicology. 72:116-123
Pretreatment of mice with 5-fluoromethylornithine (5FMOrn), a selective inactivator of ornithine aminotransferase, diminishes the accumulation of ammonia in the brain after administration of ammonium acetate, and antagonizes ammonia-induced fatal ton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea110c014662412459bea39d512e69c
https://doi.org/10.1111/j.1600-0773.1993.tb00301.x
https://doi.org/10.1111/j.1600-0773.1993.tb00301.x
Publikováno v:
Pharmacology & Toxicology. 70:373-380
5-Fluoromethylornithine (5FMOrn) is a selective inactivator of ornithine aminotransferase. Its administration causes a dramatic increase of ornithine concentrations in all tissues. Treatment of mice with 20 mg.kg-1 5FMOrn shortly before or after a le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02f723e7e4fe9969cc9f04b3fec8b2b
https://doi.org/10.1111/j.1600-0773.1992.tb00490.x
https://doi.org/10.1111/j.1600-0773.1992.tb00490.x
Publikováno v:
Neurochemical Research. 16:285-293
(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced sei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135c3e45eef18f1b9db43ac66de832e4
https://doi.org/10.1007/bf00966092
https://doi.org/10.1007/bf00966092