Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shakir Ahamad"'
Autor:
Mohammad Saquib, Shakir Ahamad, Mohammad Faheem Khan, Mohammad Imran Khan, Mohd Kamil Hussain
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Herein, we report an efficient and eco-friendly, ultrasound assisted synthetic strategy for the construction of diversified pyrrolobenzodiazepine-triazole hybrids, which are potentially pharmaceutically important scaffolds, via a domino reaction invo
Externí odkaz:
https://doaj.org/article/9c81804d25034c32a3db4f25b04ad27b
Publikováno v:
Current Neuropharmacology. 21:867-889
Abstract: Huntington’s disease (HD) is a rare and fatal neurodegenerative disorder with no disease modifying therapeutics. HD is characterized by extensive neuronal loss and is caused by the inherited expansion of the huntingtin (HTT) gene that enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::437dff4e46207f2fd544a83986da98db
https://doi.org/10.2174/1570159x21666230216104621
https://doi.org/10.2174/1570159x21666230216104621
Autor:
Shakir Ahamad, Shahnawaz A. Bhat
Publikováno v:
Journal of Medicinal Chemistry. 65:15993-16032
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). The new insights into HD's cellular and molecular pathways have led to the identification of numerous potent small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e72eb7cbe8434f74d01a58c6d3b4b15
https://doi.org/10.1021/acs.jmedchem.2c00799
https://doi.org/10.1021/acs.jmedchem.2c00799
Publikováno v:
Journal of Heterocyclic Chemistry. 59:607-632
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d31529e2f34dfc54aa6fbab79a405b7c
https://doi.org/10.1002/jhet.4416
https://doi.org/10.1002/jhet.4416
Autor:
Shakir Ahamad, Shahnawaz A. Bhat
Publikováno v:
Journal of medicinal chemistry. 65(23)
The proprotein convertase subtilisin/kexin-type 9 (PCSK9) binds to low-density lipoprotein receptors (LDLR), thereby trafficking them to lysosomes upon endocytosis and enhancing intracellular degradation to prevent their recycling. As a result, the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45292df8e4aa3065fdc5dc52ddc7a54
https://pubmed.ncbi.nlm.nih.gov/36446632
https://pubmed.ncbi.nlm.nih.gov/36446632
Autor:
Shakir Ahamad, Shahnawaz A. Bhat
Publikováno v:
Journal of Medicinal Chemistry. 66:3648-3648
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b009595b1cc1f0a052aea52d94c106
https://doi.org/10.1021/acs.jmedchem.3c00159
https://doi.org/10.1021/acs.jmedchem.3c00159
Publikováno v:
Drug discovery today. 27(5)
When secreted into the circulation, proprotein convertase subtilisin kexin type 9 (PCSK9) blocks the low-density lipoprotein receptors (LDL-R) and, as a consequence, low-density lipoprotein cholesterol (LDL-C) levels increase. Therefore, PCSK9 has em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90f0e4c5cbbab3cc4e8177b51365342
https://pubmed.ncbi.nlm.nih.gov/35121175
https://pubmed.ncbi.nlm.nih.gov/35121175
Publikováno v:
Organic Letters. 21:2962-2965
A novel silver-catalyzed domino three-component synthetic route to trifluoromethyl-substituted 1,2,3-triazolines has been realized by employing 2,2,2-trifluorodiazoethane as a 1,3-dipole for the cycloaddition reaction with the Schiff base formed from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f837619053add903b2659ac0ab8f425d
https://doi.org/10.1021/acs.orglett.9b01159
https://doi.org/10.1021/acs.orglett.9b01159
Autor:
Shakir Ahamad, Scotty Branch, Saeed Ahmed Khan, Mohammad Saquib, Shea Harrelson, Mohd. Kamil Hussain
Publikováno v:
European Journal of Medicinal Chemistry
The global effort to combat and contain the coronavirus disease 2019 (COVID-19) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now proceeding on a war footing. The world was slow to react to the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e2fa904e29269bfba8cbb874de49b2
http://europepmc.org/articles/PMC7501876
http://europepmc.org/articles/PMC7501876
Publikováno v:
ChemistrySelect. 2:11995-11998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab6baec07ed3aea7b3b22c8466b4c33
https://doi.org/10.1002/slct.201702384
https://doi.org/10.1002/slct.201702384