Výsledky vyhledávání - "Shaji K. George"

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

Autor: Shashikant Pawar, Vinod Patil, Rajender Kumar Kamboj, Milind Sindkhedkar, Trupti Bhankhede, Venkata P. Palle, Jaysagar Gundu, Spinvin Venugopal, Dhananjay Bakhle, Praveenkumar Anidil Kizhakinagath, Kumar Naik, Sanjay Bokan, Zubair Shaikh, Sagar Budhe, Vikas Shinde, Dipak Modi, M. K. Singh, Maneesh Mehta, Kamlesh J Padiya, Gururaj Vishwase, Akshaya Wagh, Rajesh Gupta, Sharad Sharma, Hemant Kumar, Sandip Kuldharan, Sadanand Mallurwar, Neelima Sinha, Gokul Deshmukh, Kaustubh Tamane, Himani Pareek, Rajesh Yeshodharan, Prashant B. Nigade, Milind Gholve, Kumar V S Nemmani, Santosh Jachak, Dilip Pandey, Nidhi Sharma, Vijay Karche, Lakshmi Narasimham, Nageswara Rao Irlapatti, Jagadeesh Daler, Rajesh Shankar, Nilesh Raghunath Khedkar, Mandar Bhonde, Vijay Kanoje, Prabakaran Kamalakannan, Chirag Shah, Shaji K George, Sachin Ingawale, Prajakta Ahirrao, Disha Dadke, Harshal Narendra Nemade, Anil Kalia, Amit Patil, Samiron Phukan, Swaroop Kumar

Publikováno v: Journal of Medicinal Chemistry. 64:17004-17030

The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c7afc213cb2f010008814556ab51c
https://doi.org/10.1021/acs.jmedchem.1c01403

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Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro

Autor: Nilesh Raghunath, Khedkar, Nageswara Rao, Irlapatti, Disha, Dadke, Vijay, Kanoje, Zubair, Shaikh, Vijay, Karche, Vikas, Shinde, Gokul, Deshmukh, Amit, Patil, Santosh, Jachak, Samiron, Phukan, Praveenkumar Anidil, Kizhakinagath, Milind, Gholve, Trupti, Bhankhede, Jagadeesh, Daler, Harshal Narendra, Nemade, Sagar, Budhe, Himani, Pareek, Rajesh, Yeshodharan, Rajesh, Gupta, Anil, Kalia, Dilip, Pandey, Akshaya, Wagh, Swaroop, Kumar, Vinod, Patil, Dipak, Modi, Nidhi, Sharma, Prajakta, Ahirrao, Maneesh, Mehta, Hemant, Kumar, Prashant, Nigade, Kaustubh, Tamane, Sadanand, Mallurwar, Sandip, Kuldharan, Shashikant, Pawar, Gururaj, Vishwase, Sanjay, Bokan, Minakshi, Singh, Kumar, Naik, Sachin, Ingawale, Rajesh, Shankar, Prabakaran, Kamalakannan, Spinvin, Venugopal, Shaji K, George, Kamlesh J, Padiya, Kumar V S, Nemmani, Jaysagar, Gundu, Mandar, Bhonde, Lakshmi, Narasimham, Milind, Sindkhedkar, Chirag, Shah, Neelima, Sinha, Sharad, Sharma, Dhananjay, Bakhle, Rajender Kumar, Kamboj, Venkata P, Palle

Publikováno v: Journal of medicinal chemistry. 64(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::caffeb96f8b24d3487ac270d9338a645
https://pubmed.ncbi.nlm.nih.gov/34843241

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Inhibition of Golgi Mannosidase II with Mannostatin A Analogues: Synthesis, Biological Evaluation, and Structure-Activity Relationship Studies

Autor: Robert J. Woods, Heather Strachan, Sameer Kawatkar, Shaji K. George, Bing Li, Aloysius Siriwardena, Geert-Jan Boons, Kelley W. Moremen

Publikováno v: ChemBioChem. 5:1220-1227

Mannostatin and aminocyclopentitetrol analogues with various substitutions at the amino function were synthesized. These compounds were tested as inhibitors of human Golgi and lysosomal alpha-mannosidases. Modification of the amine of mannostatin had

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1587ed2fb0f8adf1edf493cbc44b8b7d
https://doi.org/10.1002/cbic.200300842

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Chemoenzymatic synthesis of derivatives of a T-cell-stimulating peptide which carry tumor-associated carbohydrate antigens

Autor: Shaji K. George, Björn Holm, Tilo Schwientek, Celso A. Reis, Henrik Clausen, Jan Kihlberg

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :880-885

The Tn (GalNAcα-Ser/Thr), T [Galβ(1→3)GalNAcα-Ser/Thr], sialyl-Tn [Neu5Acα(2→6)GalNAcα-Ser/Thr] and 2,3-sialyl-T [Neu5Acα(2→3)Galβ(1→3)GalNAcα-Ser/Thr] antigens are examples of tumor-associated carbohydrate antigens expressed by epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4656f219d73d184ad3fdfe64f266532
https://doi.org/10.1039/b009567m

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Synthesis of deoxy and alanine-substituted derivatives of a T cell stimulating glycopeptide—An investigation of conditions for cleavage from the solid phase and deprotection

Autor: Jan Kihlberg, Anette Svensson, Sarbari Roy, Karl-Erik Bergquist, Petter Sjölin, Shaji K. George

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1731-1742

Little is known concerning how T cells recognize glycopeptides presented by MHC molecules on antigen-presenting cells. In order to probe the specificity of helper T cells elicited on immunization of mice with glycopeptide 1, which has the disaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f90e64858e00acdd1623bca822c9743
https://doi.org/10.1039/a900435a

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ChemInform Abstract: Chemoenzymatic Synthesis of Sialylated Glycopeptides Derived from Mucins and T-Cell Stimulating Peptides

Autor: Henrik Clausen, Jan Kihlberg, Tilo Schwientek, Bjoern Holm, Celso A. Reis, Shaji K. George

Publikováno v: ChemInform. 33

The Tn, T, sialyl-Tn, and 2,3-sialyl-T antigens are tumor-associated carbohydrate antigens expressed on mucins in epithelial cancers, such as those affecting the breast, ovary, stomach, and colon. Glycopeptides carrying these antigens are of interest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::204b5af71d643f827bbf63a461c0438a
https://doi.org/10.1002/chin.200213188

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A surface exposed O-linked galactose residue destabilises the structure of a folded helix-loop-helix dimer

Autor: Lars Baltzer, Shaji K. George, Sarojini Vijayalekshmi, Linda Andersson, Jan Kihlberg

Publikováno v: Organicbiomolecular chemistry. 1(14)

A 42-residue glycopeptide Tn-15 and the corresponding reference polypeptide Thr-15 were designed and synthesized to provide a model system for the study of how glycosylation affects the stability of a molten globule-like protein. Tn-15 and Thr-15 fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641b8a7a8363efdcaa89cd0abca70f5c
https://pubmed.ncbi.nlm.nih.gov/12956061

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Synthesis of Some Copper(II)-Chelating (Dialkylamino)pyridine Amphiphiles and Evaluation of Their Esterolytic Capacities in Cationic Micellar Media

Autor: Karnam Snehalatha, Shaji K. George, Santanu Bhattacharya

Publikováno v: The Journal of organic chemistry. 63(1)

Three new (dialkylamino)pyridine (DAAP)-based ligand amphiphiles 3-5 have been synthesized. All of the compounds possess a metal ion binding subunit in the form of a 2,6-disubstituted DAAP moiety. In addition, at least one ortho-CH(2)OH substituent i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f0c03b723f90e3f4e5c3a184a28c1c
https://pubmed.ncbi.nlm.nih.gov/11674039

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