Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Shainnel O Eans"'
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
Yi Wang, Shainnel O Eans, Heather M Stacy, Sreekanth C Narayanapillai, Abhisheak Sharma, Naomi Fujioka, Linda Haddad, Jay McLaughlin, Bonnie A Avery, Chengguo Xing
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197940 (2018)
Kava is regaining its popularity with detailed characterizations warranted. We developed an ultraperformance liquid chromatography high-resolution tandem mass spectrometry (UPLC-MS/MS) method for major kavalactones (kavain, dihydrokavain, methysticin
Externí odkaz:
https://doaj.org/article/3fffdd750ee94a64b3324ae465170f31
Autor:
Rohini S. Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L. Sobecks, Deniz Aydin, Alexander S. Powers, Abdelfattah Faouzi, Benjamin J. Polacco, Sarah M. Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O. Eans, Bowen A. Tsai, Ron O. Dror, Balazs R. Varga, Haoqing Wang, Ruth Hüttenhain, Jay P. McLaughlin, Susruta Majumdar
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1490-1503 (2024)
Externí odkaz:
https://doaj.org/article/85002e8675b5414c9f0b93723260a5ff
Autor:
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 28, Iss 22, p 7548 (2023)
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a
Externí odkaz:
https://doaj.org/article/a54656c2537040219523f325ecf69be0
Autor:
Kristen H. Scherrer, Shainnel O. Eans, Jessica M. Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1218 (2023)
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated
Externí odkaz:
https://doaj.org/article/e7827524f44543a88550968c9e396464
Autor:
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A. Majumder, Heather M. Stacy, Shainnel O. Eans, Aleksandra Nedovic, Jay P. McLaughlin, Predrag Cudic
Publikováno v:
Molecules, Vol 28, Iss 4, p 1822 (2023)
New strategies facilitate the design of cyclic peptides which can penetrate the brain. We have designed a bicyclic peptide, OL-CTOP, composed of the sequences of a selective μ-opioid receptor antagonist, CTOP (f-cyclo(CYwOTX)T) (X = penicillamine, P
Externí odkaz:
https://doaj.org/article/ff5cfdf8c2f54f439ad6e32a6ebf9ddb
Autor:
Lisa L. Wilson, Amy R. Alleyne, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 27, Iss 11, p 3617 (2022)
Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain, but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The purpose of this study was to investigate the in vivo analges
Externí odkaz:
https://doaj.org/article/b52e94dd1a3a49688fc681766bfc0bd2
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111
Autor:
Joanna Peris, Sara Wu, Jay P. McLaughlin, Aziza Abrorkhujaeva, Sam Sowell, Shainnel O. Eans, Jasmin Tawfic, Stanley M. Stevens, Bin Liu, Meera Rath
Publikováno v:
Alcohol. 95:25-36
Background Acute intoxication caused by binge ethanol drinking is linked to widespread impairments in brain functions. Various alcohol administration paradigms have been used in animals to model the heterogeneous clinical manifestation of intoxicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b989ece011addfa95f343b38a5a638f
https://doi.org/10.1016/j.alcohol.2021.05.001
https://doi.org/10.1016/j.alcohol.2021.05.001
Autor:
Abdelfattah Faouzi, Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu, Michael J. Robertson, Manish K. Madasu, Amal El Daibani, Balazs R. Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T. Slocum, Shainnel O. Eans, Michael D. Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L. Roth, Jay P. McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K. Kobilka, Susruta Majumdar
Publikováno v:
Nature.
Mu opioid receptor (µOR) agonists like fentanyl have long been used for pain management, but are considered a major public health concern due to their adverse side effects, including lethal overdose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143f7b494fdbc9f2a3c16eb8287e1d82
https://pubmed.ncbi.nlm.nih.gov/36450356
https://pubmed.ncbi.nlm.nih.gov/36450356