Výsledky vyhledávání - "Shaine Cararas"

Further structure–activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters

Autor: Dean Wade, Stacey A. Lomenzo, Abha Verma, Sari Izenwasser, Mark L. Trudell, Amy Housman, Shaine Cararas

Publikováno v: Bioorganic & Medicinal Chemistry. 19:7551-7558

The synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (DAT), the serotonin transporter (SERT) and norepinephrine transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8350c3e7330e1ef03d19c66f9e9dd384
https://doi.org/10.1016/j.bmc.2011.10.028

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Synthesis of Dopamine Transporter Selective 3-{2-(Diarylmethoxyethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes

Autor: Shaine Cararas, Amy L. Bradley, Sari Izenwasser, Mark L. Trudell, Dean Wade

Publikováno v: ChemInform. 34

A series of 3-{2-(diarylmethoxyethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes was synthesized and the binding affinities of the compounds were determined at the dopamine and serotonin transporters. The 8-phenylpropyl analogues 8a ( K i =4.1 nM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3d6e4d0000dc957c0115b5c83d99cf
https://doi.org/10.1002/chin.200325161

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