Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Shaina N Porter"'
Autor:
Shaina N Porter, Andrew S Cluster, Wei Yang, Kelsey A Busken, Riddhi M Patel, Jiyeon Ryoo, Jeffrey A Magee
Publikováno v:
eLife, Vol 5 (2016)
The FLT3 Internal Tandem Duplication (FLT3ITD) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3ITD and cooperating Flt3ITD/Runx1 mutations cau
Externí odkaz:
https://doaj.org/article/6f6798c6398a49acb152235dcdfef0fd
Publikováno v:
PLoS Genetics, Vol 5, Iss 2, p e1000376 (2009)
Zinc finger nucleases (ZFNs) have been used successfully to create genome-specific double-strand breaks and thereby stimulate gene targeting by several thousand fold. ZFNs are chimeric proteins composed of a specific DNA-binding domain linked to a no
Externí odkaz:
https://doaj.org/article/4992b949780c497fbe15232e97c7d22a
Autor:
Madeline B. Searcy, Randolph K. Larsen, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the
Externí odkaz:
https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf
Autor:
Timothy I. Shaw, Li Dong, Liqing Tian, Chenxi Qian, Yu Liu, Bensheng Ju, Anthony High, Kanisha Kavdia, Vishwajeeth R. Pagala, Bridget Shaner, Deqing Pei, John Easton, Laura J. Janke, Shaina N. Porter, Xiaotu Ma, Cheng Cheng, Shondra M. Pruett-Miller, John Choi, Jiyang Yu, Junmin Peng, Wei Gu, A. Thomas Look, James R. Downing, Jinghui Zhang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TA
Externí odkaz:
https://doaj.org/article/cb7c285f227c42abb04cd250bb2d752a
Autor:
Jean-Yves Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin Shea, John F. Tisdale, Naoya Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra Pruett-Miller, Shengdar Q. Tsai, Mitchell J. Weiss
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3379-3392 (2019)
Abstract: Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9–mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strate
Externí odkaz:
https://doaj.org/article/d8bdc8c4db524cf3ab90d0385b570174
Autor:
Theresa Okeyo-Owuor, Yanan Li, Riddhi M. Patel, Wei Yang, Emily B. Casey, Andrew S. Cluster, Shaina N. Porter, David Bryder, Jeffrey A. Magee
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2388-2399 (2019)
Abstract: MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neona
Externí odkaz:
https://doaj.org/article/7c53817e0774466ab5d2e0cc4eb8a3e9
Autor:
Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Linda Y. Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett-Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John P. Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer
Publikováno v:
bioRxiv
SUMMARYGene editing theBCL11Aerythroid enhancer is a validated approach to fetal hemoglobin (HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele distribution and HbF response may impact its safety and efficacy. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250458872ad1c0dd4644117680ac337a
https://doi.org/10.1101/2023.05.27.542323
https://doi.org/10.1101/2023.05.27.542323
Autor:
Stephen Gottschalk, Giedre Krenciute, Heather Tillman, Shondra M. Pruett-Miller, Shaina N. Porter, Jinghui Zhang, Deanna Langfitt, Alejandro Allo Anido, Timothy I. Shaw, Elizabeth Wickman, Jessica Wagner
Supplementary Figures 11-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06511e0197d3fe464aa58e26157b9748
https://doi.org/10.1158/2326-6066.22543755
https://doi.org/10.1158/2326-6066.22543755
Autor:
Stephen Gottschalk, Giedre Krenciute, Heather Tillman, Shondra M. Pruett-Miller, Shaina N. Porter, Jinghui Zhang, Deanna Langfitt, Alejandro Allo Anido, Timothy I. Shaw, Elizabeth Wickman, Jessica Wagner
Chimeric antigen receptor (CAR) T-cell therapy has had limited success in early-phase clinical studies for solid tumors. Lack of efficacy is most likely multifactorial, including a limited array of targetable antigens. We reasoned that targeting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa6c137e1bf563b38b7fdce7fae87d2
https://doi.org/10.1158/2326-6066.c.6550398
https://doi.org/10.1158/2326-6066.c.6550398
Autor:
Anang A. Shelat, Elizabeth A. Stewart, Sara M. Federico, Christopher L. Tinkle, Geoffrey Neale, Shondra M. Pruett-Miller, Shaina N. Porter, Jiyang Yu, Koon-Kiu Yan, Michele Connelly, Nathaniel Twarog, Hyekyung P. Cho, Jia Xie, Lauren Hoffmann, Kaley Blankenship, April Sykes, Natasha A. Sahr, Armita Bahrami, Michael R. Clay, Marcia Mellado-Largarde, Jessica Gartrell
Detailed methods, description of supplemental tables, and supplemental figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb8dadfb4f52e25036b299ca156af2d
https://doi.org/10.1158/1535-7163.22522210.v1
https://doi.org/10.1158/1535-7163.22522210.v1