Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Shaima Salman"'
Autor:
Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E. Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, III, Dominic Dordai, Ru Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113972- (2024)
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and m
Externí odkaz:
https://doaj.org/article/81c1beb3ca954c18aaff5e6ff94c9e4a
Autor:
Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, Jaron Sanchez, Brooks Applewhite, Kathleen Jee, Monika Deshpande, Miguel Flores-Bellver, Ming-Wen Hu, Chuanyu Guo, Shaima Salman, Yousang Hwang, Nicole M. Anders, Michelle A. Rudek, Jiang Qian, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the e
Externí odkaz:
https://doaj.org/article/208f02b363f54dcab967e446a3a95992
Autor:
Qiaozhu Zuo, Yongkang Yang, Yajing Lyu, Chen Yang, Chelsey Chen, Shaima Salman, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, III, Emmanuel Datan, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112164- (2023)
Summary: Intratumoral hypoxia is a microenvironmental feature that promotes breast cancer progression and is associated with cancer mortality. Plexin B3 (PLXNB3) is highly expressed in estrogen receptor-negative breast cancer, but the underlying mech
Externí odkaz:
https://doaj.org/article/33aaf8ed82ef405fa617b1722f2239c3
Autor:
Sarah R Poll, Renan Martin, Elizabeth Wohler, Elizabeth S Partan, Elizabeth Walek, Shaima Salman, Daniel Groepper, Lisa Kratz, Mirlene Cernach, Reynaldo Jesus-Garcia, Chad Haldeman-Englert, Yoon Jae Choi, Carol D Morris, Bernard Cohen, Julie Hoover-Fong, David Valle, Gregg L Semenza, Nara L M Sobreira
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010504 (2022)
Ollier disease (OD) and Maffucci Syndrome (MS) are rare disorders characterized by multiple enchondromas, commonly causing bone deformities, limb length discrepancies, and pathological fractures. MS is distinguished from OD by the development of vasc
Externí odkaz:
https://doaj.org/article/f07e766a88ed4dafa49601d362f73448
Autor:
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson III, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and available therapies, including immunotherapies, are ineffective for many patients. HCC is characterized by intratumoral hypoxia, and increased expression of hypoxia-ind
Externí odkaz:
https://doaj.org/article/93de6172546f4b1dba403323cea12053
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-pai
Externí odkaz:
https://doaj.org/article/618ad11c968d4029877f885f54f97652
Autor:
Yongkang Yang, Chelsey Chen, Qiaozhu Zuo, Haiquan Lu, Shaima Salman, Yajing Lyu, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, Emmanuel Datan, Ru Wang, Yufeng Wang, Nguyet Le, Yayun Zhu, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Science Advances. 8
Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is associated with poor patient outcome. HIF-1 increases the expression or activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d896dcfdf36233d0f5f333c2815f74
https://doi.org/10.1126/sciadv.abo5000
https://doi.org/10.1126/sciadv.abo5000
Autor:
Shaima Salman, Qiuran Xu, Yufeng Wang, Yongkang Yang, Gregg L. Semenza, Yajing Lyu, Qingguang Liu, Haiquan Lu, Chelsey Chen, Nguyet Le, Yayun Zhu, Ru Wang, Kangsheng Tu
Publikováno v:
Science Advances
Histone citrullination by PADI4 is required for hypoxia-induced gene expression.
Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PA
Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef28955c0e66cb8a9ed092e9e9f406fe
http://europepmc.org/articles/PMC8397272
http://europepmc.org/articles/PMC8397272
Autor:
Yuan Rui, Adrienne W. Scott, Silvia Aparicio-Domingo, Jin Yuan, Akrit Sodhi, Murilo Wendeborn Rodrigues, Monika Deshpande, Gregg L. Semenza, M. Valeria Canto-Soler, Miguel Flores-Bellver, Stephany Y. Tzeng, Yu Qin, Jing Zhang, Mireya Martinez, Silvia Montaner, Xuan Cao, Jordan J. Green, Aumreetam Dinabandhu, Yaowu Qin, Shaima Salman
Publikováno v:
J Clin Invest
Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696170121e879a0ea2417ecfbd758f2f
https://doi.org/10.1172/jci139202
https://doi.org/10.1172/jci139202
Autor:
Emmanuel, Datan, Shaima, Salman
Publikováno v:
International review of cell and molecular biology. 357
Containment and clearance of invading pathogens, such as viruses, by suppression of viral replication through antiviral mechanisms (e.g. CRISPR, interferon response or programmed cell death) provide examples of evolutionary developed responses by hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9027c94fee365341b3aeceb947be74c7
https://pubmed.ncbi.nlm.nih.gov/33234242
https://pubmed.ncbi.nlm.nih.gov/33234242