Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shaima'a Hamarsheh"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical
Externí odkaz:
https://doaj.org/article/bab2055f90cc4a4aa21071e579d430b6
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Shaima'a Hamarsheh, Robert Zeiser
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Inflammation is involved in tumor development and progression as well as antitumor response to therapy. In the past decade, the crosstalk between inflammation, immunity, and cancer has been investigated extensively, which led to the identification of
Externí odkaz:
https://doaj.org/article/5665d2d98e3749b2aa9a53010fce210c
Autor:
Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d9300956a84504938585998fec2dc2
https://doi.org/10.1158/1541-7786.c.6544992.v1
https://doi.org/10.1158/1541-7786.c.6544992.v1
Autor:
Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald
S1. KrasG12D recipient mice develop a myelodysplastic syndrome within the transferred WT hematopoietic system. S2. Gating strategy used for the isolation of bone marrow (BM) niche cells. S3. The frequency of BM niche cells is not affected in KrasG12D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b3296df9d02a5d90b9267cc3fde8e8
https://doi.org/10.1158/1541-7786.22526058
https://doi.org/10.1158/1541-7786.22526058
Autor:
Shaima'a Hamarsheh, Robert Zeiser
Publikováno v:
Inflammasome Biology ISBN: 9780323918022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5447c6af1330a36d25c636471fc927f4
https://doi.org/10.1016/b978-0-323-91802-2.00005-0
https://doi.org/10.1016/b978-0-323-91802-2.00005-0
Autor:
Antonio Abbate, Ivona Aksentijevich, Marcelo Pires Amaral, Magaiver Andrade-Silva, Diego Angosto-Bazarra, Luca Antonioli, Kübra Aral, Juan I. Aróstegui, Jillian Barlow, Laura Benvenuti, Nunzia Bernardini, Massimo Bertinaria, Monika Biasizzo, Karina Ramalho Bortoluci, Dave Boucher, Laura Migliari Branco, David Brough, Petr Broz, Clare E. Bryant, Mark Cahill, Matthew Campbell, Soo Jung Cho, Shelbi Christgen, Rebecca C. Coll, Isabelle Couillin, Brianna Cyr, Sarah Dalmon, Juan Pablo de Rivero Vaccari, Francesco Di Virgilio, Andrea Dorfleutner, Sarah L. Doyle, Vanessa D'Antongiovanni, Ariel E. Feldstein, Matteo Fornai, Carlos García-Palenciano, Simone Gastaldi, Matthias Geyer, François Ghiringhelli, Anna Lisa Giuliani, José Manuel González-Navajas, Iva Hafner-Bratkovič, Shaima'a Hamarsheh, Michael T. Heneka, Thomas Henry, Jun-ichi Hikima, Inga V. Hochheiser, Alexander Hogg, Alexander Hooftman, Christopher Hoyle, Yin Huang, Sarah Huot-Marchand, Laura Hurtado-Navarro, Sushmita Jha, Thirumala-Devi Kanneganti, Benedikt Kaufmann, Andrea D. Kim, Nataša Kopitar-Jerala, Jordana Kron, Silvia Lucena Lage, Beatriz Lozano-Ruiz, Elisabetta Marini, Billie Matchett, Adolfo G. Mauro, Eleonora Mezzaroma, Michael R. Milward, Ingrid Kazue Mizuno Watanabe, Natsuki Morimoto, Sandip Mukherjee, Mar Orzáez, Luke A.J. O'Neill, Pablo Pelegrín, Carolina Pellegrini, Anaïs Perrichet, Joanna Picó, Nicola Potere, Alexander Pronko, Kishore Aravind Ravichandran, Nicolas Riteau, Kim S. Robinson, Cédric Rébé, Fadi N. Salloum, Mónica Sancho, Andrew Sandstrom, Niels Olsen Saraiva Câmara, Florian I. Schmidt, Liang Shan, Eoin Silke, Paula M. Soriano-Teruel, Christian Stehlik, Heather Stout-Delgado, Arianne L. Theiss, Jenny P.-Y. Ting, Stefano Toldo, Elviche L. Tsakem, Rebecca E. Tweedell, Amalia Tzoumpa, K. Venuprasad, Rose Wellens, Robert Zeiser, Franklin L. Zhong, Alessia Zotta
Publikováno v:
Inflammasome Biology ISBN: 9780323918022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df40277879d3530be000cf63f0ec15f
https://doi.org/10.1016/b978-0-323-91802-2.01002-1
https://doi.org/10.1016/b978-0-323-91802-2.01002-1
Autor:
Shaima’a Hamarsheh, Justus Duyster, Lukas Braun, Franziska M. Uhl, Sandra Duquesne, Geoffroy Andrieux, Robert Zeiser, Melanie Boerries, Annette Schmitt-Graeff, Lena Osswald, Christine Dierks, Tilman Brummer, Claudius Klein
Publikováno v:
Molecular Cancer Research. 19:1596-1608
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Autor:
Daniel, Hofbauer, Dimitrios, Mougiakakos, Luca, Broggini, Mario, Zaiss, Maike, Büttner-Herold, Christian, Bach, Bernd, Spriewald, Frank, Neumann, Savita, Bisht, Jens, Nolting, Robert, Zeiser, Shaima'a, Hamarsheh, Martin, Eberhardt, Julio, Vera, Cristina, Visentin, Chiara Maria Giulia, De Luca, Fabio, Moda, Stefan, Haskamp, Cindy, Flamann, Martin, Böttcher, Katrin, Bitterer, Simon, Völkl, Andreas, Mackensen, Stefano, Ricagno, Heiko, Bruns
Publikováno v:
Immunity. 54(8)
As substantial constituents of the multiple myeloma (MM) microenvironment, pro-inflammatory macrophages have emerged as key promoters of disease progression, bone destruction, and immune impairment. We identify beta-2-microglobulin (β2m) as a driver
Autor:
Savita Bisht, Stefano Ricagno, Heiko Bruns, Mario M. Zaiss, Shaima’a Hamarsheh, Andreas Mackensen, Christian Bach, Martin Eberhardt, Dimitrios Mougiakakos, Luca Broggini, Simon Völkl, Martin Böttcher, Jens Nolting, Daniel Hofbauer, Maike Büttner-Herold, Fabio Moda, Chiara De Luca, Katrin Bitterer, Robert Zeiser, Julio Vera, Frank Neumann
Publikováno v:
SSRN Electronic Journal.
As significant constituents of the tumor microenvironment in multiple Myeloma (MM), pro-inflammatory macrophages are key promoters of disease progression, bone destruction, and immune-impairment. Consequently, the identification of endogenous mediato