Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Shailja Pathania"'
Autor:
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1
Externí odkaz:
https://doaj.org/article/3508a45a6daf4e298c016ff52086528b
Autor:
Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese
Externí odkaz:
https://doaj.org/article/939969bbc4324201be410156a45cd9e5
Autor:
Pamoda Galhenage, Yunlan Zhou, Erica Perry, Brenda Loc, Kelly Fietz, Sonia Iyer, Ferenc Reinhardt, Tiego Da Silva, Vladimir Botchkarev, Jie Chen, Christopher P. Crum, Robert A. Weinberg, Shailja Pathania
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113144- (2023)
Summary: Clinical and molecular evidence indicates that high-grade serous ovarian cancer (HGSOC) primarily originates from the fallopian tube, not the ovarian surface. However, the reasons for this preference remain unclear. Our study highlights sign
Externí odkaz:
https://doaj.org/article/fdbf18dd16e443c1a8e30ac69230764e
Autor:
Kazi Nazrul Islam, Anuoluwapo Ajao, Kavita Venkataramani, Joshua Rivera, Shailja Pathania, Katrin Henke, Kellee Renee Siegfried
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010589 (2023)
The double stranded RNA binding protein Adad1 (adenosine deaminase domain containing 1) is a member of the adenosine deaminase acting on RNAs (Adar) protein family with germ cell-specific expression. In mice, Adad1 is necessary for sperm differentiat
Externí odkaz:
https://doaj.org/article/56c59e4eb9684c4e8fd09604b784a50b
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-9 (2022)
Abstract Carriers of germline BRCA2 pathogenic sequence variants have elevated aggressive prostate cancer risk and are candidates for precision oncology treatments. We examined whether BRCA2-deficient (BRCA2 d ) prostate tumors have distinct genomic
Externí odkaz:
https://doaj.org/article/e8bd40b686474509a6110e6ca54a55c3
Autor:
Haohui Duan, Shailja Pathania
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guara
Externí odkaz:
https://doaj.org/article/38d73af2d1344ffba7d9cdaff026b32a
Autor:
Karen Cichowski, Stephen J. Elledge, Shailja Pathania, Keith T. Flaherty, Levi A. Garraway, Elodie Hatchi, Christian Bowman-Colin, Thomas De Raedt, Terence C. Wong, Caroline J. Guild, Alessandra G. Gavin, Chloe E. Emerson, Haley E. Manchester, Ryan Kuzmickas, Ophélia Maertens
Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0effcf971400872c1a7839e9c4838839
https://doi.org/10.1158/2159-8290.22533134.v1
https://doi.org/10.1158/2159-8290.22533134.v1
Autor:
Robert A. Weinberg, David Pépin, Anniina Farkkila, Benjamin G. Neel, Paula T. Hammond, Shailja Pathania, Pamoda M. Galhenage, Jaana Oikkonen, Johanna Hynninen, Kaisa Huhtinen, Fernando Pérez-Villatoro, George W. Bell, M. Inmaculada Barrasa, Marie-Charlotte Meinsohn, Julia Casado, Bimarzhan Assatova, Esmee Hoefsmit, Ferenc Reinhardt, Sean G. Smith, Heiko Horn, Simge Yucel, Shuang Zhang, Sonia Iyer
Despite advances in immuno-oncology, the relationship between tumor genotypes and response to immunotherapy remains poorly understood, particularly in high-grade serous tubo-ovarian carcinomas (HGSC). We developed a series of mouse models that carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03903dbf1cead4fa599c26374a273b2b
https://doi.org/10.1158/2159-8290.c.6548069.v1
https://doi.org/10.1158/2159-8290.c.6548069.v1
Autor:
Karen Cichowski, Stephen J. Elledge, Shailja Pathania, Keith T. Flaherty, Levi A. Garraway, Elodie Hatchi, Christian Bowman-Colin, Thomas De Raedt, Terence C. Wong, Caroline J. Guild, Alessandra G. Gavin, Chloe E. Emerson, Haley E. Manchester, Ryan Kuzmickas, Ophélia Maertens
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a6bfd6164f7f4e7b36e686fb19a1fb
https://doi.org/10.1158/2159-8290.22533128.v1
https://doi.org/10.1158/2159-8290.22533128.v1
Publikováno v:
Molecular Cell. 82:4-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8442fe988c35555150b4aa41ddd1eca
https://doi.org/10.1016/j.molcel.2021.12.013
https://doi.org/10.1016/j.molcel.2021.12.013