Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Shailesh N. Mistry"'
Autor:
Fadi Soukarieh, Ruiling Liu, Manuel Romero, Shaun N. Roberston, William Richardson, Simone Lucanto, Eduard Vico Oton, Naim Ruhul Qudus, Alaa Mashabi, Scott Grossman, Sadiqur Ali, Tomás Sou, Irena Kukavica-Ibrulj, Roger C. Levesque, Christel A. S. Bergström, Nigel Halliday, Shailesh N. Mistry, Jonas Emsley, Stephan Heeb, Paul Williams, Miguel Cámara, Michael J. Stocks
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Current treatments for Pseudomonas aeruginosa infections are becoming less effective because of the increasing rates of multi-antibiotic resistance. Pharmacological targeting of virulence through inhibition of quorum sensing (QS) dependent virulence
Externí odkaz:
https://doaj.org/article/2028c900e1c64f45a368b4dc67692ee3
Autor:
Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N. Mistry, Andrew R. Bottrill, Patrick M. Sexton, Arthur Christopoulos, Jeffrey Conn, Craig W. Lindsley, Sophie J. Bradley, Andrew B. Tobin
Publikováno v:
Science Signaling. 15
Many dementias are propagated through the spread of “prion-like” misfolded proteins. This includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer’s disease (AD), for which no treatments are available to slow or stop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c168e561d75a13f908e050a3542ed50
https://doi.org/10.1126/scisignal.abm3720
https://doi.org/10.1126/scisignal.abm3720
Autor:
Zhi Yuan, Kok, Leigh A, Stoddart, Sarah J, Mistry, Tamara A M, Mocking, Henry F, Vischer, Rob, Leurs, Stephen J, Hill, Shailesh N, Mistry, Barrie, Kellam
Publikováno v:
Journal of medicinal chemistry. 65(12)
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7280e0a0c9c4e28233b053dc813a0673
https://pubmed.ncbi.nlm.nih.gov/35734860
https://pubmed.ncbi.nlm.nih.gov/35734860
G protein coupled receptors (GPCRs) are widely therapeutically targeted, and recent advances in allosteric modulator development at this class of receptors offer further potential for exploitation. In particular GPCR intracellular allosteric modulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c6e7b1972658bdc0dfc1be12d101d3
https://doi.org/10.1101/2022.05.30.494024
https://doi.org/10.1101/2022.05.30.494024
Autor:
Sophie J. Bradley, Shailesh N. Mistry, Patrick M. Sexton, Elham Khajehali, Colin Molloy, Miriam Scarpa, Andrew R. Bottrill, P. Jeffery Conn, Pawel Herzyk, Mario Rossi, Arthur Christopoulos, Craig W. Lindsley, Louis Dwomoh, Andrew B. Tobin
The most prevalent types of dementias, including Alzheimer’s disease, are those that are propagated via the spread of “prion-like” misfolded proteins. Despite considerable effort no treatments are available to slow or stop the progression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ffd93afdb37e9547c32a948682b7d5
https://doi.org/10.1101/2021.07.30.454298
https://doi.org/10.1101/2021.07.30.454298
Autor:
Shailesh N. Mistry, Peter J. Scammells, Barrie Kellam, Tim J. Fyfe, Ben Capuano, David A. Sykes, Steven J. Charlton, J. Robert Lane
Publikováno v:
Journal of Medicinal Chemistry. 62:9488-9520
Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side effects (EPSs) and hyperprolactinemia relative to atypical APDs such as clozapine. Both dr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97c4da5fc68d4b9a2116f0f5cd1ffc7
https://doi.org/10.1021/acs.jmedchem.9b00864
https://doi.org/10.1021/acs.jmedchem.9b00864
Autor:
Peter J. Scammells, Barrie Kellam, Tim J. Fyfe, Ben Capuano, J. Robert Lane, Shailesh N. Mistry
Publikováno v:
European Journal of Medicinal Chemistry. 168:474-490
We recently described a structurally novel series of negative allosteric modulators (NAMs) of the dopamine D2 receptor (D2R) based on thieno[2,3-d]pyrimidine 1, showing it can be structurally simplified to reveal low molecular weight, fragment-like N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827e9392ef4509f84b3f80455ed9edfd
https://doi.org/10.1016/j.ejmech.2019.01.061
https://doi.org/10.1016/j.ejmech.2019.01.061
Publikováno v:
Pharmaceuticals
The 27th annual GP2A (Groupement des Pharmacochimistes de l′Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) conference took place from 21 to 23 August 2019, at the East Midlands Conference Centre (University Park, Nottingham, United
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b30ca4b35806fdbf362da1d5b41fe5f
http://europepmc.org/articles/PMC6958382
http://europepmc.org/articles/PMC6958382
Autor:
Tim J, Fyfe, Barrie, Kellam, David A, Sykes, Ben, Capuano, Peter J, Scammells, J Robert, Lane, Steven J, Charlton, Shailesh N, Mistry
Publikováno v:
Journal of medicinal chemistry. 62(21)
Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side effects (EPSs) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::784b78fa93808b64f655d4306febc299
https://pubmed.ncbi.nlm.nih.gov/31580666
https://pubmed.ncbi.nlm.nih.gov/31580666
Autor:
Tim J, Fyfe, Barrie, Kellam, Shailesh N, Mistry, Peter J, Scammells, J Robert, Lane, Ben, Capuano
Publikováno v:
European journal of medicinal chemistry. 168
We recently described a structurally novel series of negative allosteric modulators (NAMs) of the dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::487877c949b60eb1252817a2e956769c
https://pubmed.ncbi.nlm.nih.gov/30849613
https://pubmed.ncbi.nlm.nih.gov/30849613