Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Shailendra K. Gupta"'
Autor:
Nivedita Singh, Faiz M Khan, Lakshmi Bala, Julio Vera, Olaf Wolkenhauer, Brigitte Pützer, Stella Logotheti, Shailendra K. Gupta
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-20 (2023)
Abstract Melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene regulatory networks (GRNs). Appro
Externí odkaz:
https://doaj.org/article/53a7ebe4e78a44ae85ff7ce82585f5bf
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Melanoma phenotype and the dynamics underlying its progression are determined by a complex interplay between different types of regulatory molecules. In particular, transcription factors (TFs), microRNAs (miRNAs), and long non-cod
Externí odkaz:
https://doaj.org/article/8a84b42d4ef5481287154cb3f71f634a
Autor:
Gati Krushna Panigrahi, Neeraj Verma, Nivedita Singh, Somya Asthana, Shailendra K. Gupta, Anurag Tripathi, Mukul Das
Publikováno v:
Toxicology Reports, Vol 5, Iss , Pp 164-172 (2018)
Consumption of Cassia occidentalis (CO) seeds has been associated with the hepatomyoencephalopathy (HME) in children. Recently, we have characterized the toxic anthraquinones (AQs) such as Emodin, Rhein, Aloe-emodin, Chrysophanol and Physcion in CO s
Externí odkaz:
https://doaj.org/article/f984eacb7d064e2aa1bbcbe3b1d424c8
Autor:
Faiz M. Khan, Stephan Marquardt, Shailendra K. Gupta, Susanne Knoll, Ulf Schmitz, Alf Spitschak, David Engelmann, Julio Vera, Olaf Wolkenhauer, Brigitte M. Pützer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specifi
Externí odkaz:
https://doaj.org/article/6feb9a206c964085ae20896ed0722b38
Autor:
Mehdi Sharifi Tabar, Wunna Kyaw, Krishna P. Singh, Charles G. Bailey, Shailendra K. Gupta, Tatyana Laletin, Olaf Wolkenhauer, Punkaja M S Amarasekera, Charles G. Mullighan, Cynthia Metierre, Habib Francis, Ulf Schmitz, John E.J. Rasko, Crystal Semaan, Patrick O’Young
Publikováno v:
Cellular and Molecular Life Sciences
CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have n
Publikováno v:
Biological Chemistry. 402:887-909
The placenta is a highly vascularized and complex foetal organ that performs various tasks, crucial to a healthy pregnancy. Its dysfunction leads to complications such as stillbirth, preeclampsia, and intrauterine growth restriction. The specific cau
Autor:
Dirk Heckl, Krishna P. Singh, Michael Alpers, Brigitte M. Pützer, Olaf Wolkenhauer, Alf Spitschak, Shailendra K. Gupta, David Engelmann, Christoph Söhnchen, Christin Richter, Berdien A. H. Edelhäuser, Stella Logotheti, Julia Brenmoehl, Nico Murr, Stephan Marquardt
Publikováno v:
Theranostics
Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic
Publikováno v:
SSRN Electronic Journal.
Autor:
O. Wolkenhauer, Matti Hoch, Suchi Smita Gupta, Konstantin Cesnulevicius, Shailendra K. Gupta, David Lescheid, Myron Schultz
Disease maps have emerged as computational knowledge bases for exploring and modeling diseasespecific molecular processes. By capturing molecular interactions, disease-associated processes, and phenotypes in standardized representations, disease maps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7805a98e38cc7fcb7a8c7025e9bebdf
https://doi.org/10.1101/2021.09.13.460023
https://doi.org/10.1101/2021.09.13.460023
Autor:
Stella Logotheti, Shailendra K. Gupta, Faiz M. Khan, Lakshmi Bala, Olaf Wolkenhauer, Brigitte M. Pützer, Nivedita Singh, Julio Vera
Skin melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream pro-metastatic gene regulatory networks (GRNs). Appropri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c576ec2875c57ca36162662c6d3c4a1