Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shailen K. Joshi"'
Autor:
Zhiren Xia, Wende Niforatos, Qingwei Zhang, Steve McGaraughty, Katharine L. Chu, Jun Xu, Ivan Milicic, Shailen K. Joshi, Victoria E. Scott, Michael F. Jarvis
Publikováno v:
Biochemical Pharmacology. 89:536-544
Activation of T-type Ca²⁺ channels contributes to nociceptive signaling by facilitating action potential bursting and modulation of membrane potentials during periods of neuronal hyperexcitability. The role of T-type Ca²⁺ channels in chronic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3a6d12fbc163ba564bbc6869f4a55f
https://doi.org/10.1016/j.bcp.2014.03.015
https://doi.org/10.1016/j.bcp.2014.03.015
Autor:
Brett Antonio, Robert J. Gregg, Gricelda H. Simler, Matthew S Johnson, Yi Liu, Dong Liu, Marc J. C. Scanio, Prisca Honore, Alison Knox, James B. Thomas, Shailen K. Joshi, Mark L. Chapman, Brian E. Marron, Irene Drizin, Douglas S. Krafte, Connie R. Faltynek, Robert N. Atkinson, Xu-Feng Zhang, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Stephen Werness, Kennan C. Marsh, Lei Shi, Char-Chang Shieh
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7816-7825
Na(v)1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons. It has been implicated in the pathophysiology of inflammatory and neuropathic pain, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebd1fee852efa5ef6ea85bd394f0b15
https://doi.org/10.1016/j.bmc.2010.09.057
https://doi.org/10.1016/j.bmc.2010.09.057
Autor:
Rosemarie Roeloffs, Stephen Werness, Brian E. Marron, Chengmin Zhong, Brett Antonio, Ahmed H. Hakeem, Irene Drizin, Char-Chang Shieh, Mark L. Chapman, Joseph P. Mikusa, Marc J. C. Scanio, James B. Thomas, Shailen K. Joshi, Dong Liu, Mark A. Matulenko, Douglas S. Krafte, Robert N. Atkinson, Lei Shi, Kennan C. Marsh, Gricelda H. Simler, Matthew S Johnson, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Xu-Feng Zhang, Robert J. Gregg, Connie R. Faltynek, Matthew A. Secrest, Prisca Honore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6812-6815
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d6b9da5e44daf33aabb753a354c07
https://doi.org/10.1016/j.bmcl.2010.08.121
https://doi.org/10.1016/j.bmcl.2010.08.121
Autor:
Brian E. Marron, Kort Michael E, Michael F. Jarvis, Prisca Honore, Mark L. Chapman, Char-Chang Shieh, Ahmed H. Hakeem, Mark A. Matulenko, Xu-Feng Zhang, Connie R. Faltynek, Shailen K. Joshi, Douglas S. Krafte, Robert N. Atkinson
Publikováno v:
Neuropharmacology. 59:201-207
Activation of sodium channels is essential to action potential generation and propagation. Recent genetic and pharmacological evidence indicates that activation of Na(v)1.8 channels contributes to chronic pain. Herein, we describe the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b10f65e3d8c0358fb61cd6f1ed532df
https://doi.org/10.1016/j.neuropharm.2010.05.009
https://doi.org/10.1016/j.neuropharm.2010.05.009
Autor:
Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi
Publikováno v:
Pain. 142:27-35
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. TRPV1 antagonists have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cec77f1eb7a5454a08a328e395101
https://doi.org/10.1016/j.pain.2008.11.004
https://doi.org/10.1016/j.pain.2008.11.004
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003
https://doi.org/10.1016/j.bmc.2008.05.003
Autor:
Prasant Chandran, Gricelda Hernandez, Michael W. Decker, Shailen K. Joshi, C.T. Wismer, Prisca Honore, C.Z. Zhu, Anita K. Salyers, C. Zhong, Joseph P. Mikusa
Publikováno v:
Neuroscience. 143:587-596
Intradermal capsaicin injection produces immediate spontaneous pain behaviors, and a secondary mechanical hypersensitivity (SMH) that is employed in the clinic as a model potentially predictive of human neuropathic pain. Presently, we have characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3b2733659bd33554653ac6f00f13c
https://doi.org/10.1016/j.neuroscience.2006.08.005
https://doi.org/10.1016/j.neuroscience.2006.08.005
Autor:
Prisca Honore, Shailen K. Joshi
Publikováno v:
Expert Opinion on Drug Discovery. 1:323-334
One of the greatest challenges to discovering more efficacious medications for pain control has been the heterogeneity of the chronic pain condition in humans. It is now appreciated that distinct mechanisms contribute to normal physiological pain, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3d48760f3f46256bfb07febdd94fa3
https://doi.org/10.1517/17460441.1.4.323
https://doi.org/10.1517/17460441.1.4.323
Autor:
Emily E. Cole, Chengmin Zhong, Timothy A. Vortherms, Ivan Milicic, Min Zhang, Chang Z. Zhu, Joseph P. Mikusa, Donna M. Gauvin, Chih-Hung Lee, Cenchen Zhan, Michael F. Jarvis, Katharine L. Chu, Robert S. Bitner, Madhavi Pai, La Geisha Lewis, Anton Bespalov, Anthony W. Bannon, Torben R. Neelands, Shailen K. Joshi, Searle Xenia B, Steve McGaraughty, Victoria E. Scott, Wende Niforatos, Jun Xu, Victoria A. Roderwald, Andrew M. Swensen
Publikováno v:
The journal of pain. 15(4)
Voltage-gated Ca 2+ channels play an important role in nociceptive transmission. There is significant evidence supporting a role for N-, T- and P/Q-type Ca 2+ channels in chronic pain. Here, we report that A-1264087, a structurally novel state-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ebc35303dd87b3a62588855368676
https://pubmed.ncbi.nlm.nih.gov/24374196
https://pubmed.ncbi.nlm.nih.gov/24374196
Autor:
Xuesong Liu, Vincent L. Giranda, Kaitlin E. Browman, Alex R. Shoemaker, Chengmin Zhong, Yan Shi, Joseph P. Mikusa, Donna M. Gauvin, Jill-Desiree Brederson, Thomas D. Penning, Shailen K. Joshi
Publikováno v:
Journal of the peripheral nervous system : JPNS. 17(3)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major toxicity of chemotherapy treatment for which no therapy is approved. Poly(ADP-ribose) polymerase (PARP)1/2 are nuclear enzymes activated upon DNA damage, and PARP1/2 inhibition provides res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2f38ef690104b3b42c457a63c0bda9
https://pubmed.ncbi.nlm.nih.gov/22971094
https://pubmed.ncbi.nlm.nih.gov/22971094