Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Shailaja Hegde"'
Autor:
Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112794- (2023)
Summary: Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and pat
Externí odkaz:
https://doaj.org/article/ce35a814bf814b97aa20a01a202f9e01
Autor:
Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf, Paul A Roche, Yamileth Rangel, Leolene J Carrington, Hartmut Geiger, H Leighton Grimes, Sanjiv Luther, Ivan Maillard, Joaquin Sanchez-Garcia, Daniel T Starczynowski, Jose A Cancelas
Publikováno v:
eLife, Vol 10 (2021)
Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emerge
Externí odkaz:
https://doaj.org/article/08b4f0f9fe184ce5b3fbfcccc7aca175
Autor:
Anjelika Gasilina, Gurdat Premnauth, Purujit Gurjar, Jacek Biesiada, Shailaja Hegde, David Milewski, Gang Ma, Tanya V Kalin, Edward Merino, Jarek Meller, William Seibel, José A Cancelas, Lisa Privette Vinnedge, Nicolas N Nassar
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229801 (2020)
We report the synthesis and preliminary characterization of IODVA1, a potent small molecule that is active in xenograft mouse models of Ras-driven lung and breast cancers. In an effort to inhibit oncogenic Ras signaling, we combined in silico screeni
Externí odkaz:
https://doaj.org/article/77ce89f10b264baaa9e3f7923cb8dd53
Autor:
Shailaja Hegde, Robert F. Paulson
Publikováno v:
BioTechniques, Vol 36, Iss 6, Pp 936-940 (2004)
Externí odkaz:
https://doaj.org/article/1f8c0cb1b2a24737bef41f84923a147b
Publikováno v:
Current opinion in hematology. 29(6)
Hemorrhage is a major cause of preventable death in trauma and cancer. Trauma induced coagulopathy and cancer-associated endotheliopathy remain major therapeutic challenges. Early, aggressive administration of blood-derived products with hypothesized
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Craig T. Jordan, Mary J. Kennett, Avinash K. Kudva, Emily R. Finch, Shailaja Hegde, Naveen Kaushal, Ujjawal H. Gandhi
PDF file - 772KB, Supplementary Figure 1. Selenium supplementation abrogates leukemia in a Friend leukemia (FVP) model. Supplementary Figure 2. Effect of selenium supplementation on the splenic histopathology in FVP-infected mice. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309987a607a3b378168c79648b61279e
https://doi.org/10.1158/0008-5472.22404105
https://doi.org/10.1158/0008-5472.22404105
Autor:
Mohammad Reza Ahmadian, William L. Seibel, Yi Zheng, John P. Perentesis, Benjamin Mizukawa, Lisa M. Privette Vinnedge, Shailaja Hegde, Jose A. Cancelas, Oliver H.F. Krumbach, Yuan Lin, Mark Wunderlich, Nicolas Nassar, Anjelika Gasilina, Marcel Buchholzer, Mohammad Akbarzadeh
Publikováno v:
Leukemia. 36:637-647
Aberrant RHO guanine nucleotide exchange factor (RhoGEF) activation is chief mechanism driving abnormal activation of their GTPase targets in transformation and tumorigenesis. Consequently, a small-molecule inhibitor of RhoGEF can make an anti-cancer
Publikováno v:
Transfusion
Background Cold storage of platelets (PLTs) has the potential advantage of prolonging storage time while reducing posttransfusion infection given the decreased likelihood of bacterial outgrowth during storage and possibly beneficial effects in treati
Publikováno v:
Current Opinion in Hematology. 25:500-508
Purpose of review Platelet transfusion is a widely used therapy in treating or preventing bleeding and haemorrhage in patients with thrombocytopenia or trauma. Compared with the relative ease of platelet transfusion, current practice for the storage
Autor:
H. Leighton Grimes, Juana Serrano-Lopez, Jose A. Cancelas, Hartmut Geiger, Paul A. Roche, Sanjiv A. Luther, Sachin Kumar, Shailaja Hegde, Daniel T. Starczynowski, Jing Fang, Josefina Serrano, Leolene J Carrington, Ivan Maillard, Joaquin Sanchez-Garcia, Ashley M Wellendorf, Yamileth Rangel
Publikováno v:
eLife, vol. 10, pp. e66190
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emerge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b21e383c88ab48091f61fe7dfa80116
https://serval.unil.ch/notice/serval:BIB_95B2C7F1BB21
https://serval.unil.ch/notice/serval:BIB_95B2C7F1BB21