Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shaila Yeasmin"'
Autor:
Tamara Pérez-Jeldres, Christopher J. Tyler, Joshua D. Boyer, Thangaraj Karuppuchamy, Andrés Yarur, Daniel A. Giles, Shaila Yeasmin, Luke Lundborg, William J. Sandborn, Derek R. Patel, Jesús Rivera-Nieves
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The inflammatory Bowel diseases (IBDs) are a chronic, relapsing inflammatory diseases of the gastrointestinal tract with heterogeneous behavior and prognosis. The introduction of biological therapies including anti-TNF, anti-IL-12/23, and anti-integr
Externí odkaz:
https://doaj.org/article/f29b17441b56475daa8d6cd3b7056487
Autor:
Nadia R Zgajnar, Jesús Rivera-Nieves, Luke R Lundborg, Mauricio Guzman, Paul Jedlicka, Giorgos Bamias, Shaila Yeasmin, Christopher J. Tyler
Publikováno v:
Mucosal Immunology
T and B cells employ integrin α4β7 to migrate to intestine under homeostatic conditions. Whether those cells differentially rely on α4β7 for homing during inflammatory conditions has not been fully examined. This may have implications for our und
Autor:
Luke Lundborg, Mauricio Guzman, Shaila Yeasmin, Nadia R. Zgajnar, Katarzyna Dobaczewska, Paul Jedlicka, Jesus Rivera-Nieves
Publikováno v:
Gastroenterology. 162:S-49
Autor:
Jesús Rivera-Nieves, Giorgos Bamias, Christopher J. Tyler, Katarzyna Dobaczewska, Mauricio Guzman, Luke R Lundborg, Shaila Yeasmin, Zbigniew Mikulski, Vanessa Taupin, Nadia R Zgajnar
Publikováno v:
Mucosal Immunology
Efficient IgA transcytosis is critical for the maintenance of a homeostatic microbiota. In the canonical model, locally-secreted dimeric (d)IgA reaches the polymeric immunoglobulin receptor (pIgR) on intestinal epithelium via simple diffusion. A role
Inherent Immune Cell Variation Within Colonic Segments Presents Challenges for Clinical Trial Design
Autor:
Brian W Behm, Tamara Pérez-Jeldres, Derek Patel, Giorgos Bamias, Parambir S. Dulai, Luke R Lundborg, Shaila Yeasmin, Andres Yarur, Jesús Rivera-Nieves, Mauricio Guzman, Christopher J. Tyler
Publikováno v:
J Crohns Colitis
Background and Aims Intestinal biopsy sampling during IBD trials represents a valuable adjunct strategy for understanding drug responses at the tissue level. Given the length and distinctive embryonic origins of the proximal and distal colon, we inve
Publikováno v:
The Journal of Immunology. 204:233.24-233.24
The incidence of ulcerative colitis (UC) is increasing worldwide. A proven therapeutic strategy for UC is the inhibition of leukocyte trafficking via blockade of integrin β7. Despite this, the mechanism of action of vedolizumab (anti-α4β7) is poor
Publikováno v:
The Journal of Immunology. 204:79.24-79.24
S1P is a bioactive sphingolipid that participates as a critical regulator of many physiological processes, mainly in lymphocyte egress from lymphoid tissue, mediated by S1P gradients through the activity of S1P lyase (SPL). Inhibition of both S1P-spe
Publikováno v:
The Journal of Immunology. 202:67.13-67.13
BACKGROUND The inflammatory bowel diseases (IBD) can affect various segments of the gastrointestinal tract, and the biology behind regional differences in disease remains poorly understood, in part due to a lack of understanding of regional variation