Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shaila S. Shabbir"'
Autor:
Naomi A. Fineberg, Trevor W. Robbins, Karen D. Ersche, Barbara J. Sahakian, John Suckling, Graham K. Murray, Edward T. Bullmore, Sanja Abbott, Franziska Knolle, Kevin J. Craig, Shaila S. Shabbir
Publikováno v:
Psychopharmacology
RationalePatients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior cingulate cortex as a key lo
Autor:
Dave Singh, Noushin Brealey, Peter T. Daley-Yates, Brian Keppler, Shaila S. Shabbir, Neil Barnes
Publikováno v:
Airway pharmacology and treatment.
This is the first study to compare the relative systemic metabolomic and lipidomic bioactivity dose-responses for ICS. Plasma for metabolomic and lipidomic analysis was obtained from 54 subjects (GSK study 203162, NCT02991859) who received weekly esc
Autor:
Daren Austin, Shaila S. Shabbir, Dave Singh, Neil Barnes, Peter T. Daley-Yates, Tim Harrison, Noushin Brealey, Sebin Thomas, B. Kumar
Publikováno v:
61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V..
Autor:
Neil Barnes, Tim Harrison, Daren Austin, Dave Singh, Sebin Thomas, Noushin Brealey, Peter T. Daley-Yates, Shaila S. Shabbir
Publikováno v:
British journal of clinical pharmacology. 87(2)
Aims To compare the airway potency, systemic activity and therapeutic index of three inhaled corticosteroids that differ in glucocorticoid receptor binding affinity, physicochemical and pharmacokinetic properties. Methods This escalating-dose, placeb
Autor:
Bharath Kumar, Peter T. Daley-Yates, Daren Austin, Tim Harrison, Neil Barnes, Shaila S. Shabbir, Dave Singh, Noushin Brealey, Sebin Thomas
Publikováno v:
Airway pharmacology and treatment.
FF is an inhaled corticosteroid (ICS) with higher glucocorticoid receptor affinity, tissue permeability and lung retention than other ICS. We investigated whether these attributes improve the therapeutic index (TI), defined as systemic activity to to
Autor:
Peter T. Daley-Yates, Sebin Thomas, Daren Austin, Dave Singh, Noushin Brealey, Neil Barnes, Shaila S. Shabbir, B. Kumar, L. Iaz-Chachuat, Tim Harrison
Publikováno v:
Revue Française d'Allergologie. 60:347
Introduction FF est un corticosteroide inhale (CSI) avec une affinite, une permeabilite tissulaire et une retention pulmonaire plus grande que les autres CSI. Nous avons cherche a savoir si ces proprietes ameliorent l’index therapeutique (IT), defi
Autor:
Barry V. O'Neill, Pradeep J. Nathan, Mushi Dustagheer, Jonathan Bullman, Jeffrey Price, Anshita Gupta, Chao Chen, Subramanya Kumar, Odile Dewit, Sam R. Miller, Shaila S. Shabbir, Chris M. Dodds, Philip Lawrence
Publikováno v:
Human psychopharmacology. 34(3)
Objective This double-blind, randomised, placebo-controlled, two-part study assessed the impact of GSK2981710, a medium-chain triglyceride (MCT) that liberates ketone bodies, on cognitive function, safety, and tolerability in healthy older adults. Me
Autor:
Peter B. Jones, Edward T. Bullmore, Pradeep J. Nathan, John Suckling, Cinly Ooi, Anna Barnes, Belinda R Lennox, Shaila S. Shabbir, Emmeline Goodby, AM Dean, Linda Scoriels
Publikováno v:
BASE-Bielefeld Academic Search Engine
BackgroundPsychotic disorders are highly heritable such that the unaffected relatives of patients may manifest characteristics, or endophenotypes, that are more closely related to risk genes than the overt clinical condition. Facial affect processing
Autor:
Karen D. Ersche, Shaila S. Shabbir, Naomi A. Fineberg, Trevor W. Robbins, Emilio Merlo-Pich, Kevin J. Craig, Edward T. Bullmore, David Meunier, Alex Fornito
Publikováno v:
NeuroImage. 59:1461-1468
There are reasons for thinking that obsessive-compulsive disorder (OCD) and drug dependence, although conventionally distinct diagnostic categories, might share important cognitive and neurobiological substrates. We tested this hypothesis directly by
Autor:
Charlene Wu, Shaila S. Shabbir, Pat M. Woollard, Alan D. Borthwick, Simon Peace, Fabrizio Nerozzi, David E. Davies, Timothy D. Westfall, John Liddle, Wendy R. Irving, Deirdre Mary Bernadette Hickey, Joanne Philp, Christopher Charles Frederick Hamlett, Derek Pollard, Mark Pullen, David P. Brooks, Gerald P. McCafferty, Richard M. Edwards, Andrew M. Mason, Steve L. Sollis, Michael Allen, Anne M. Exall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:90-94
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat.