A promising class of antiprotozoal agents, design and synthesis of novel Pyrimidine-Cinnamoyl hybrids.

Autor: Kayamba F; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa; Department of Chemistry and Biology, School of Natural and Applied Sciences, Mulungushi University, PO Box, 80415, Kabwe, Zambia., Karpoormath R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa. Electronic address: karpoormath@ukzn.ac.za., Obakachi VA; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa., Mahlalela M; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa., Banda D; Department of Chemistry and Biology, School of Natural and Applied Sciences, Mulungushi University, PO Box, 80415, Kabwe, Zambia., van Zyl RL; WITS Research Institute for Malaria (WRIM), Faculty of Health Sciences, University of Witwatersrand, Johannesburg, 2193, South Africa; Pharmacology Division, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa., Lala S; WITS Research Institute for Malaria (WRIM), Faculty of Health Sciences, University of Witwatersrand, Johannesburg, 2193, South Africa; Pharmacology Division, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa., Zininga T; Department of Biochemistry, Stellenbosch University, Stellenbosch, 7600, South Africa., Shonhai A; Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Private Bag X5050, Thohoyandou, 0950, South Africa., Shaik BB; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa., Pooe OJ; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jan 05; Vol. 281, pp. 116944. Date of Electronic Publication: 2024 Oct 08.

Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal.

Autor: Bagratee T; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Prawlall R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Ndlovu T; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Sibisi S; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Ndadane S; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Shaik BB; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Palkar MB; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa.; Department of Pharmaceutical Chemistry, SVKM's NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Vile Parle (West), Mumbai, 400056, Maharashtra, India., Gampa R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa., Karpoormath R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban, 4000, South Africa.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Aug; Vol. 21 (8), pp. e202400460. Date of Electronic Publication: 2024 Jul 03.

A concise review on marine bromopyrrole alkaloids as anticancer agents.

Autor: Mahamed S; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Motal R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Govender T; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Dlamini N; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Khuboni K; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Hadeb Z; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Shaik BB; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Moodley K; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Balaso Mohite S; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Karpoormath R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa. Electronic address: Karpoormath@ukzn.ac.za.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jan 15; Vol. 80, pp. 129102. Date of Electronic Publication: 2022 Dec 07.

Role of Natural Products in Developing Novel Anticancer Agents: A Perspective.

Autor: Shaik BB; Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.; School of Chemistry & Physics, Westville Campus, University of KwaZulu-Natal, Chiltern Hills, Durban, 4000, South Africa., Katari NK; Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, Telangana, 502329, India.; School of Chemistry & Physics, Westville Campus, University of KwaZulu-Natal, Chiltern Hills, Durban, 4000, South Africa., Jonnalagadda SB; School of Chemistry & Physics, Westville Campus, University of KwaZulu-Natal, Chiltern Hills, Durban, 4000, South Africa.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2022 Nov; Vol. 19 (11), pp. e202200535. Date of Electronic Publication: 2022 Nov 08.

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach.

Autor: Rana, Nisarg¹ (AUTHOR), Patel, Dhaval² (AUTHOR), Parmar, Meet² (AUTHOR), Mukherjee, Nandini¹ (AUTHOR), Jha, Prakash C.³ (AUTHOR), Manhas, Anu¹ (AUTHOR) anu.manhas15@gmail.com

Publikováno v: Scientific Reports. 10/23/2023, Vol. 13 Issue 1, p1-22. 22p.