Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Shaifali Bhalla"'
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Publikováno v:
Journal of Pharmacy and Pharmacology. 74:769-778
Objectives Intracerebroventricular injection of endothelin-A receptor antagonist BQ123 potentiates opioid analgesia and reverses analgesic tolerance. This study explores whether these effects can be replicated by injecting BQ123 intravenously. Method
Publikováno v:
Heliyon, Vol 3, Iss 6, Pp e00317- (2017)
Aim: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in ex
Externí odkaz:
https://doaj.org/article/64b4548f2ab34ecdbf8721184b17e8af
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Life Sciences. 159:34-42
Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal.
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 93:935-944
Long-term use of opioids for pain management results in rapid development of tolerance and dependence leading to severe withdrawal symptoms. We have previously demonstrated that endothelin-A (ETA) receptor antagonists potentiate opioid analgesia and
Publikováno v:
The FASEB Journal. 34:1-1
Publikováno v:
Drug Research. 66:189-195
Manipulation of the central endothelin (ET) system via either ETA antagonists or ETB agonists following experimental cerebral ischemia has been shown to be beneficial in previous experimental studies. In order to further explore the involvement of th
Publikováno v:
Heliyon, Vol 3, Iss 6, Pp e00317-(2017)
Aim: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in ex