Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Shai Yarkoni"'
Brief ex vivo Fas-ligand incubation attenuates GvHD without compromising stem cell graft performance
Autor:
Anastasia Rodin, Jerry Stein, Amnon Peled, Yuval Baar, Liat Shachnai-Pinkas, Alex Saar, Nitzan Marelly, Tsila Zuckerman, Galina Rodionov, Shai Yarkoni, Michal Rosenzwaig, Michal Abraham, Liron Gez, Tamar Katz, Hila Wildbaum, Ronit Bakimer-Kleiner, Inbal Mishalian, Hilit Levy-Barazany
Publikováno v:
Bone Marrow Transplantation
Graft versus host disease (GvHD) remains a limiting factor for successful hematopoietic stem cell transplantation (HSCT). T cells and antigen-presenting cells (APCs) are major components of the hematopoietic G-CSF mobilized peripheral blood cell (MPB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22957bcc3ce777ab64b25d353e71e078
https://doi.org/10.1038/s41409-020-0941-2
https://doi.org/10.1038/s41409-020-0941-2
Autor:
Galina Rodionov, Michal Rosenzwaig, Michal Schrift Tzadok, Moran Kvint, Elazar Gevir, Elina Zorde-Khvalevsky, Amnon Peled, Shai Yarkoni, Amos Ofer
Publikováno v:
Bone marrow transplantation. 57(8)
Mobilized peripheral blood cells (MPBCs) graft and peripheral blood cells apheresis are used for bone marrow transplantation and for treatment of graft versus host disease (GvHD). We demonstrate that a short treatment of MPBCs with Fas ligand (FasL,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e1115ac1eccc8dd8ff0645a15dc160
https://pubmed.ncbi.nlm.nih.gov/35538142
https://pubmed.ncbi.nlm.nih.gov/35538142
Autor:
Ilan Volovitz, Meirav Sela, Nir Shani, Shai Yarkoni, Dov Zipori, Sharon Manheim, Eyal Gur, Benjamin Meilik, Inna Solodeev
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)
Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)
Fas-L is a TNF family member known to trigger cell death. It has recently become evident that Fas-L can transduce also non-apoptotic signals. Mesenchymal stem cells (MSCs) are multipotent cells that are derived from various adult tissues. Although MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1a77d7d84ca6fc3ef103c38d66624f
https://doi.org/10.1038/s41419-018-0702-y
https://doi.org/10.1038/s41419-018-0702-y
Publikováno v:
Immunologic Research. 58:101-105
One of the therapeutic approaches to type 1 diabetes (T1D) focuses on enhancement of regulatory T cell (Treg) activity, either by adoptive transfer or supplementation of supporting cytokines such as interleukin-2 (IL-2). In principle, this therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2d3594255ba7228fdb3dcba8bf4a59
https://doi.org/10.1007/s12026-013-8476-x
https://doi.org/10.1007/s12026-013-8476-x
Publikováno v:
Biology of Blood and Marrow Transplantation. 18(4):523-535
T cell depletion prevents graft-versus-host disease (GVHD) but also removes T cell-mediated support of hematopoietic cell engraftment. A chimeric molecule composed of IL-2 and caspase-3 (IL2-cas) has been evaluated as a therapeutic modality for GVHD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898a2399dc388ec26a52104d3ac41a6a
Autor:
Galina Rodionov, Liat Pinkas, Hila Wildbaum, Amnon Peled, Shai Yarkoni, Nitzan Marelly, Jerry Stein, Hilit Levy-Barazany, Michal Tzadok, Tsila Zuckerman, Ronit Bakimer, Tamar Katz
Publikováno v:
Blood. 132:2033-2033
Graft versus host disease (GvHD) proceeds to be the Achilles' heel of hematopoietic stem cell transplantation, with clinicians continue facing a classic conflict: too much GvHD and the patient is at risk for transplant-related mortality and decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee1114ddf21aea7148a5e8dd255d60e
https://doi.org/10.1182/blood-2018-99-117920
https://doi.org/10.1182/blood-2018-99-117920
Autor:
Tsila Zuckerman, Jerry Stein, Liat Pinkas, Alex Saar, Amotz Nechushtan, Isaac Yaniv, Jacob M. Rowe, Yuval Baar, Inbal Mishalian, Tami Katz, Shai Yarkoni, Hilit Levy-Barazany, Amnon Peled, Yaron Pereg, Michal Abraham, Hila Wildbaum
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9303f6c47fa67e18225d13cf8966e0f7
https://doi.org/10.1016/j.bbmt.2017.12.149
https://doi.org/10.1016/j.bbmt.2017.12.149
Publikováno v:
European Journal of Immunology. 39:2850-2864
Pathogenic lymphocytes in the enteric wall of inflammatory bowel disease patients display various abnormalities, including reduced sensitivity to apoptosis. We evaluated a therapeutic approach to elimination of cytotoxic cells, using two IL-2 fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fb6f8cb3df96c5675695a8db04eaeb
https://doi.org/10.1002/eji.200839190
https://doi.org/10.1002/eji.200839190
Publikováno v:
Annals of the New York Academy of Sciences. 1173:791-797
Targeted depletion of immune cells expressing the interleukin-2 (IL-2) receptor can exacerbate inflammatory bowel disease (IBD) through elimination of regulatory T (Treg) cells, or ameliorate its course by depletion of cytotoxic cells. To answer this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d60379fe2f7d0573686b2f4c0a960f
https://doi.org/10.1111/j.1749-6632.2009.04877.x
https://doi.org/10.1111/j.1749-6632.2009.04877.x
Publikováno v:
Immunology & Cell Biology. 86:650-658
Activation-induced cell death is a general mechanism of immune homeostasis through negative regulation of clonal expansion of activated immune cells. This mechanism is involved in the maintenance of self- and transplant tolerance through polarization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6067ad66ad0344f77aff29465b88655
https://doi.org/10.1038/icb.2008.62
https://doi.org/10.1038/icb.2008.62