Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Shai Shaham"'
Autor:
Menachem Katz, Francis Corson, Wolfgang Keil, Anupriya Singhal, Andrea Bae, Yun Lu, Yupu Liang, Shai Shaham
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural a
Externí odkaz:
https://doaj.org/article/2b7596e726bc4d719dfc4d8b1846dd17
Autor:
Stephan Raiders, Erik Calvin Black, Andrea Bae, Stephen MacFarlane, Mason Klein, Shai Shaham, Aakanksha Singhvi
Publikováno v:
eLife, Vol 10 (2021)
Glia in the central nervous system engulf neuron fragments to remodel synapses and recycle photoreceptor outer segments. Whether glia passively clear shed neuronal debris or actively prune neuron fragments is unknown. How pruning of single-neuron end
Externí odkaz:
https://doaj.org/article/61edeb9badab4ebcac74701274c35c1f
Stress-Induced Neural Plasticity Mediated by Glial GPCR REMO-1 Promotes C. elegans Adaptive Behavior
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108607- (2021)
Summary: Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to envi
Externí odkaz:
https://doaj.org/article/9f6de87fbd824c0fada59ac927942a2c
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2575-2583 (2018)
Summary: Glia have been suggested to regulate sleep-like states in vertebrates and invertebrates alike. In the nematode Caenorhabditis elegans, sleep is associated with molting between larval stages. To understand if glia modulate neural circuits dri
Externí odkaz:
https://doaj.org/article/2463d1d0e1ab458382e6d84c668e7e24
Autor:
Anupriya Singhal, Shai Shaham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tools to label single neurons and track their development inC. elegans have been lacking. Singhal et al. optimized a method, which applies infrared laser to induce heat-dependent gene expression at cellular resolution in developing C. elegansembryos,
Externí odkaz:
https://doaj.org/article/8cd9d2f1fdaa483f981d867badf112b3
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 550-562 (2016)
Sensory neurons are an animal’s gateway to the world, and their receptive endings, the sites of sensory signal transduction, are often associated with glia. Although glia are known to promote sensory-neuron functions, the molecular bases of these i
Externí odkaz:
https://doaj.org/article/af92a23ad7554d7ead404a04ec52cd1a
Autor:
Peter Insley, Shai Shaham
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194861 (2018)
The Caenorhabditis elegans cell lineage is nearly invariant. Whether this stereotyped cell-division pattern promotes reproducibility in cell shapes/positions is not generally known, as manual spatiotemporal cell-shape/position alignments are labor-in
Externí odkaz:
https://doaj.org/article/a06b3f0c6e0441eea9b018f71f025efd
Autor:
Maxime J Kinet, Jennifer A Malin, Mary C Abraham, Elyse S Blum, Melanie R Silverman, Yun Lu, Shai Shaham
Publikováno v:
eLife, Vol 5 (2016)
Apoptosis is a prominent metazoan cell death form. Yet, mutations in apoptosis regulators cause only minor defects in vertebrate development, suggesting that another developmental cell death mechanism exists. While some non-apoptotic programs have be
Externí odkaz:
https://doaj.org/article/08ce472132164c55aa5b86a6550954be
Autor:
Andrew R Schwendeman, Shai Shaham
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164595 (2016)
Programmed cell death is a ubiquitous process in metazoan development. Apoptosis, one cell death form, has been studied extensively. However, mutations inactivating key mammalian apoptosis regulators do not block most developmental cell culling, sugg
Externí odkaz:
https://doaj.org/article/df010f0bc7c042b280245e3a68cb8e67
Autor:
Melissa Kelley, John Yochem, Michael Krieg, Andrea Calixto, Maxwell G Heiman, Aleksandra Kuzmanov, Vijaykumar Meli, Martin Chalfie, Miriam B Goodman, Shai Shaham, Alison Frand, David S Fay
Publikováno v:
eLife, Vol 4 (2015)
During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx
Externí odkaz:
https://doaj.org/article/cdd7a4efc098416da962749cc95e830a