CHD8 regulates gut epithelial cell function and affects autism-related behaviors through the gut-brain axis

Autor: Ipsita Chatterjee, Dmitriy Getselter, Nasreen Ghanayem, Ram Harari, Liron Davis, Shai Bel, Evan Elliott

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Autism is a neurodevelopmental disorder characterized by early-onset social behavioral deficits and repetitive behaviors. Chromodomain helicase DNA-binding protein (CHD8) is among the genes most strongly associated with autism. In addition t

Externí odkaz: https://doaj.org/article/80c8c844e35d4dc5ac9358754773988a

TMF/ARA160 Governs the Dynamic Spatial Orientation of the Golgi Apparatus during Sperm Development.

Autor: Yoav Elkis, Shai Bel, Roni Rahimi, Tali Lerer-Goldstein, Smadar Levin-Zaidman, Tatiana Babushkin, Sally Shpungin, Uri Nir

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145277 (2015)

TMF/ARA160 is known to be a TATA element Modulatory Factor (TMF). It was initially identified as a DNA-binding factor and a coactivator of the Androgen receptor. It was also characterized as a Golgi-associated protein, which is essential for acrosome

Externí odkaz: https://doaj.org/article/53d9b8ad9df442299d5767d912fff087

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

Autor: Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Asulin, Sondra Turjeman, Michal Werbner, Supapit Wongkuna, Rachel Feeney, Bjoern O. Schroeder, Abraham Nyska, Meital Nuriel-Ohayon, Shai Bel

Publikováno v: Cell Host & Microbe. 31:433-446.e4

Colonic goblet cells are specialized epithelial cells that secrete mucus to physically separate the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet cells control the amount of mucus they secrete is unclear. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec9d93e5a476af6e1f46e86338f5014
https://doi.org/10.1016/j.chom.2023.01.006

List of contributors

Autor: Rina Aharoni, Zulfiqar Ahmad, Suhail Akhtar, N. D. Prasad Atmuri, Carmen Avendaño, Ivneet Banga, Shai Bel, Łukasz Berlicki, Yair Blumberg, Carine Bourguet, Marlon Henrique Cardoso, Samraggi Choudhury, Sitan Diarra, Marvin N. Driessen, Michael K. Dunn, Vandon T. Duong, Offir Ertracht, Emer S. Ferro, Octavio Luiz Franco, Tatiana Galochkina, Sonu Gandhi, Shikun Ge, Jean-Christophe Gelly, Mayara C.F. Gewehr, Rujuta Ghorpade, Eric R. Gross, Wessal Hanout, Tamia A. Harris, Adrienne Joseph, Srinivasaraghavan Kannan, Abidemi Paul Kappo, Krishna Kumar, Maushmi S. Kumar, Dilraj Lama, Jolene L. Lau, Jianguo Li, Adi Litmanovich, Jamie Liu, William D. Lubell, Lloyd Mabonga, Subhasis Mahari, Priscilla Masamba, J. Carlos Menéndez, Gassan Moady, Satheesh Kumar Nanjappan, Ami Navon, Ines Neundorf, Meital Nuriel-Ohayon, Dmitriy Orlov, David Paul, Ron Piran, William Farias Porto, Nir Qvit, Samuel J.S. Rubin, Mussa Saad, Deepshikha Shahdeo, Olga Shamova, Kathleen M. Sicinski, Abhishek Singh, Worood Sirhan, Shruti Surendran, Simon Surprenant, Yaw Sing Tan, Mukesh Thakur, Ekaterina Umnyakova, Özge Ünsal, Chandra S Verma, Nana-Maria Wagner, Zhipeng A. Wang, Bryan J. Xie, Long Xu, Vanessa O. Zambelli, Xiaoying Zhang, Ji-Shen Zheng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cd1766f7274d84b4d2ea94b9168ec00
https://doi.org/10.1016/b978-0-12-820141-1.00034-0

Progesterone supplementation in mice leads to microbiome alterations and weight gain in a sex-specific manner

Autor: Shai Bel, Anna Belogolovski, M. Ben Izhak, Meital Nuriel-Ohayon, Oshrit Shtossel, Oren Ziv, Omry Koren, Yoram Louzoun, Hadar Neuman, Sondra Turjeman, S. Komissarov

BackgroundProgesterone is a steroid hormone produced by the ovaries, involved in pregnancy progression and necessary for successful gestation. We have previously shown that progesterone affects gut microbiota composition and leads to increased relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72c765be0062a508e86fc62abc683b96
https://doi.org/10.1101/2021.10.06.463337