SYK kinase mediates brown fat differentiation and activation

Autor: Marko Knoll, Sally Winther, Anirudh Natarajan, Huan Yang, Mengxi Jiang, Prathapan Thiru, Aliakbar Shahsafaei, Tony E. Chavarria, Dudley W. Lamming, Lei Sun, Jacob B. Hansen, Harvey F. Lodish

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Spleen protein tyrosine kinase (Syk) has so far been mainly studied in haematopoietic and immune cells. Here, the authors show that Syk also has a role in brown adipose tissue, where it regulates the formation of brown adipocytes and their thermogeni

Externí odkaz: https://doaj.org/article/877a0b3be1764ea4bc9c077a7efffb20

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

Autor: Patterson, Heide Christine, Gerbeth, Carolin, Thiru, Prathapan, Vögtle, Nora F., Knoll, Marko, Shahsafaei, Aliakbar, Samocha, Kaitlin E., Huang, Cher X., Harden, Mark Michael, Song, Rui, Chen, Cynthia, Kao, Jennifer, Shi, Jiahai, Salmon, Wendy, Shaul, Yoav D., Stokes, Matthew P., Silva, Jeffrey C., Bell, George W., MacArthur, Daniel G., Ruland, Jürgen, Meisinger, Chris, Lodish, Harvey F.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2015 Oct . 112(42), E5679-E5688.

Externí odkaz: https://www.jstor.org/stable/26465580

The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms

Autor: Dorfman, David M., Hornick, Jason L., Shahsafaei, Aliakbar, Freeman, Gordon J.

Publikováno v: In Human Pathology 2010 41(10):1486-1494

SYK kinase mediates brown fat differentiation and activation

Autor: Anirudh Natarajan, Prathapan Thiru, Jacob B. Hansen, Marko Knoll, Dudley W. Lamming, Harvey F. Lodish, Mengxi Jiang, Tony E. Chavarria, Sally Winther, Aliakbar Shahsafaei, Lei Sun, Huan Yang

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Knoll, M, Winther, S, Natarajan, A, Yang, H, Jiang, M, Thiru, P, Shahsafaei, A, Chavarria, T E, Lamming, D W, Sun, L, Hansen, J B & Lodish, H F 2017, ' SYK kinase mediates brown fat differentiation and activation ', Nature Communications, vol. 8, 2115 . https://doi.org/10.1038/s41467-017-02162-3
Nature Communications

Brown adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and humans. Sympathetic stimulation of β-adrenergic receptors in response to cold induces proliferation, differentiation, and UCP1 expression in pre-ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad015412e5211b08b6e829b24c77da57
http://link.springer.com/article/10.1038/s41467-017-02162-3

Enhancer of zeste homolog 2 is widely expressed in T-cell neoplasms, is associated with high proliferation rate and correlates with MYC and pSTAT3 expression in a subset of cases.

Autor: Shi, Min¹ (AUTHOR), Shahsafaei, Ali¹ (AUTHOR), Liu, Cuiling² (AUTHOR), Yu, Hongbo³ (AUTHOR), Dorfman, David M.¹ (AUTHOR) ddorfman@partners.org

Publikováno v: Leukemia & Lymphoma. Jul2015, Vol. 56 Issue 7, p2087-2091. 5p.