Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shahrnaz Kemal"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis,
Externí odkaz:
https://doaj.org/article/c687288b476a44bbbdc01ae2166912dd
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2416 (2008)
Members of the dynamin super-family of GTPases are involved in disparate cellular pathways. Dynamin1 and dynamin2 have been implicated in clathrin-mediated endocytosis. While some models suggest that dynamin functions specifically at the point of ves
Externí odkaz:
https://doaj.org/article/3e9e4144011f4e8e8edeb1736b025543
Autor:
Robert Vassar, Antonio Di Meco, Shahrnaz Kemal, Jelena Popovic, Sidhanth Chandra, Katherine Sadleir
Publikováno v:
Curr Alzheimer Res
Background: Alzheimer’s disease (AD) is initiated by aberrant accumulation of amyloid beta (Aβ) protein in the brain parenchyma. The microenvironment surrounding amyloid plaques is characterized by the swelling of presynaptic terminals (dystrophic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a7403807b181ceab5ff78110bd99c
https://pubmed.ncbi.nlm.nih.gov/35579170
https://pubmed.ncbi.nlm.nih.gov/35579170
Publikováno v:
Current Opinion in Cell Biology. 78:102119
Both neurons and glia in mammalian brains are highly ramified. Neurons form complex neural networks using axons and dendrites. Axons are long with few branches and form pre-synaptic boutons that connect to target neurons and effector tissues. Dendrit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f320ee2af6efece04f568ace43637996
https://doi.org/10.1016/j.ceb.2022.102119
https://doi.org/10.1016/j.ceb.2022.102119
Autor:
Robert Vassar, Shahrnaz Kemal
Publikováno v:
The Journal of Experimental Medicine
Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21163aaeae81b19e5097f61fe40049e
https://pubmed.ncbi.nlm.nih.gov/31601677
https://pubmed.ncbi.nlm.nih.gov/31601677
Autor:
Katherine R. Sadleir, Jasvinder K. Atwal, Leah K. Cuddy, Devi Krishna Priya Karunakaran, Ryan J. Watts, Robert Vassar, Shahrnaz Kemal
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267dbaf38094aa249258407cb674ce05
https://doi.org/10.1016/j.jalz.2018.06.167
https://doi.org/10.1016/j.jalz.2018.06.167
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8fff354576e0111776b6f66fa9af07
https://doi.org/10.1038/ncomms12551
https://doi.org/10.1038/ncomms12551
Publikováno v:
Nature neuroscience, vol 13, iss 12
Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7c1e69b3ec1a0f2b68144f0d3fe3a1
https://doi.org/10.1038/nn.2665
https://doi.org/10.1038/nn.2665
Publikováno v:
American journal of physiology. Cell physiology. 291(5)
The endocytic adaptor complex AP-2 colocalizes with the majority of clathrin-positive spots at the cell surface. However, we previously observed that AP-2 is excluded from internalizing clathrin-coated vesicles (CCVs). The present studies quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c87c227be713f3bac5a7cd6b8f82be
https://pubmed.ncbi.nlm.nih.gov/17035303
https://pubmed.ncbi.nlm.nih.gov/17035303
Autor:
Micahel Vershinin, Steven P. Gross, Shahrnaz Kemal, Richard J. McKenney, Ambarish Kunwar, Richard B. Vallee
Publikováno v:
Biophysical Journal. (3):726a-727a
Cytoplasmic dynein is involved in a wide range of intracellular movements including fast vesicular transport and slow nuclear translocation. How one motor contributes to fast, low load movement as well as slow, high-load movement is unknown. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94b9c673a9b2be61f788ec10d750cdd