Výsledky vyhledávání - "Shahriar Tahvilian"

Akademický článek

p300 and cAMP response element‐binding protein‐binding protein in skeletal muscle homeostasis, contractile function, and survival

Autor: Kristoffer Svensson, Samuel A. LaBarge, Abha Sathe, Vitor F. Martins, Shahriar Tahvilian, Jennifer M. Cunliffe, Roman Sasik, Sushil K. Mahata, Gretchen A. Meyer, Andrew Philp, Larry L. David, Samuel R. Ward, Carrie E. McCurdy, Joseph E. Aslan, Simon Schenk

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 464-477 (2020)

Abstract Background Reversible ε‐amino acetylation of lysine residues regulates transcription as well as metabolic flux; however, roles for specific lysine acetyltransferases in skeletal muscle physiology and function are unknown. In this study, w

Externí odkaz: https://doaj.org/article/19b284faa0d3446e92f314afabd7c769

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Akademický článek

Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase

Autor: Vitor F. Martins, Shahriar Tahvilian, Ji H. Kang, Kristoffer Svensson, Byron Hetrick, Wallace S. Chick, Simon Schenk, Carrie E. McCurdy

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Introduction: The Phosphoinositide 3-kinase (PI3K) signaling pathway plays an important role in skeletal muscle insulin-stimulated glucose uptake. While whole-body and tissue specific knockout (KO) of individual or combinations of the regulatory subu

Externí odkaz: https://doaj.org/article/351c4fc78ac246cf92cc52962d9faab1

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p300 and cAMP response element‐binding protein‐binding protein in skeletal muscle homeostasis, contractile function, and survival

Autor: Roman Sasik, Simon Schenk, Abha Sathe, Samuel LaBarge, Samuel R. Ward, Carrie E. McCurdy, Jennifer M. Cunliffe, Gretchen A. Meyer, Joseph E. Aslan, Shahriar Tahvilian, Kristoffer Svensson, Larry L. David, Andrew Philp, Sushil K. Mahata, Vitor F. Martins

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 464-477 (2020)

Background Reversible ε‐amino acetylation of lysine residues regulates transcription as well as metabolic flux; however, roles for specific lysine acetyltransferases in skeletal muscle physiology and function are unknown. In this study, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d8a3ce79e5e8728b1efd16cb9a530c
http://europepmc.org/articles/PMC7113519

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Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

Autor: Kristoffer Svensson, Simon Schenk, Carrie E. McCurdy, Keenan Greyslak, Neeka Barooni, Vitor F. Martins, Jessica R. Dent, Shahriar Tahvilian, Adrianna Lemanek

Publikováno v: Am J Physiol Endocrinol Metab

Sirtuin 1 (SIRT1) and general control of amino acid synthesis 5 (GCN5) regulate mitochondrial biogenesis via opposing modulation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) acetylation status and activity. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4b961422bac0c3f70b5c3c6956d8e8
https://europepmc.org/articles/PMC7052578/

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Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3

Autor: Kristoffer Svensson, Shahriar Tahvilian, Carrie E. McCurdy, Keenan Greyslak, Simon Schenk, Byron Hetrick, Samuel LaBarge, Abha Sathe, Jessica R. Dent

Publikováno v: J Appl Physiol (1985)

Signal transducer and activator of transcription 3 (STAT3) was recently found to be localized to mitochondria in a number of tissues and cell types, where it modulates oxidative phosphorylation via interactions with the electron transport proteins, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc94368edc8d74b73ab5a22b53eca5db
https://pubmed.ncbi.nlm.nih.gov/31513449

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Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity

Autor: Carrie E. McCurdy, Shivani Lakkaraju, Kristoffer Svensson, Shahriar Tahvilian, Simon Schenk, Vitor F. Martins, Samuel LaBarge, Maedha Begur, Byron Hetrick, Jessica R. Dent, Elisa H. Buckner

Publikováno v: Am J Physiol Endocrinol Metab

Akt is a critical mediator of insulin-stimulated glucose uptake in skeletal muscle. The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f9d417d2193e69e51adec568dfb7b3
https://pubmed.ncbi.nlm.nih.gov/30888860

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Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

Autor: Shahriar Tahvilian, Kristoffer Svensson, Julien Ochala, Abha Sathe, Jessica R. Dent, Mulchand S. Patel, Simon Schenk, Vitor F. Martins

Publikováno v: American journal of physiology. Endocrinology and metabolism. 315(5)

The pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA and is an important control point for carbohydrate (CHO) oxidation. However, the importance of the PDC and CHO oxidation to muscle metabolism and exercise performance, particula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967e4d2bcb3a54ab267f131aacdc3594
https://pubmed.ncbi.nlm.nih.gov/30153068

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