Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shahriar Pooyan"'
Publikováno v:
ACS chemical neuroscience. 11(4)
Stability of the microtubule protein (MTP) network required for its physiological functions is disrupted in the course of neurodegenerative disorders. Thus, the design of novel therapeutic approaches for microtubule stabilization is a focus of intens
Autor:
Gholam Hossein Riazi, Jamshid Davoodi, Loghman Firoozpour, Mohammad Taheri, Shayan Abbasi, Sama Pirkalkhoran, Homa Farahani, Hossein Lanjanian, Shahriar Pooyan
Publikováno v:
Bioconjugate chemistry. 31(3)
The attachment of PEG to biopharmaceuticals has been applied for enhancement of bioavailability and improved stability. The PEG polymer is highly hydrated; thus effective attachment to inaccessible sites could be hindered. We have devised a scheme to
Publikováno v:
Brain research bulletin. 154
Despite the attention given to the treatment of multiple sclerosis (MS), still no certain cure is available. The main purpose of MS drugs is acting against neuroinflammation which underlies the pathology of MS. Neuroinflammation is associated with en
Autor:
Nahid Fakhraei, Sogol Meknatkhah, Gholam Hossein Riazi, Alireza Imani, Shahriar Pooyan, Nahid Tofigh, Monireh-Sadat Mousavi
Publikováno v:
Stress (Amsterdam, Netherlands). 22(1)
Multiple adult health problems are associated with adolescent stress. As the brain discriminates physical and psychological stressors by activation of different neural networks, we hypothesized that behavioral and physiological performance would be m
Autor:
Mohammad Mehdi Tavakol, Seyed Shahriar Arab, Gholam Hossein Riazi, Azam Azimi, Seyed Mahmood Ghaffari, Shahriar Pooyan
Publikováno v:
Journal of ethnopharmacology. 194
Ethnopharmacological relevance Cyperus rotundus L. (Cyperaceae), commonly known as purple nutsedge or nut grass is one of the most invasive and endemic weeds in tropical, subtropical and temperate regions. This plant has been extensively used in trad
Autor:
Mark R. Plummer, Patrick J. Sinko, Yong-Jiu Jin, Xiaoping Zhang, Simi Gunaseelan, Shahriar Pooyan
Publikováno v:
Molecular Pharmaceutics. 6:836-848
Cell-penetrating peptides (CPPs) can enter many types of cells and have become useful tools for introducing a variety of cargo such as exogenous peptides, proteins, and nucleic acids into cultured cells in vitro. Tat CPPs derived from the HIV-1 Tat p
Publikováno v:
Pharmaceutical Research. 24:2110-2119
To assess in vivo macrophage targeting potential of PEG-fMLF nanocarriers and to investigate their biodistribution, peritoneal macrophage uptake, and pharmacokinetics.Multiple copies of fMLF were conjugated to purchased and novel (branched, peptide-b
Autor:
Carol R. Gardner, Yaming Su, Xiaoping Zhang, Michael J. Leibowitz, Patrick J. Sinko, Stanley Stein, Shahriar Pooyan, Li Wan
Publikováno v:
Scopus-Elsevier
Penetration of epithelial cells represents the rate-determining step for the absorption of many drugs and pharmaceutical macromolecules such as proteins and nucleic acid therapeutics. While the potential of using cell-penetrating peptides (CPPs) to f
Autor:
Patrick J. Sinko, Vadivel Ganapathy, Srinivasan Ramanathan, Puttur D. Prasad, Michael J. Leibowitz, Shahriar Pooyan, Stanley Stein, Jihong Wang
Publikováno v:
Pharmaceutical Research. 18:950-956
Purpose. To investigate the potential for delivering large peptides orally by altering their absorptive transport pathways and improving intestinal permeability. The absorptive transport of retro-inverso (R.I.-) K-Tat9 and R.I.-K(biotin)-Tat9, novel
Autor:
Jihong Wang, Michael J. Leibowitz, Shaei Yun Huang, Indrani Choudhury, Stanley Stein, Shahriar Pooyan
Publikováno v:
Bioconjugate Chemistry. 9:612-617
Two different methods were developed to prepare an adduct of a poly(ethylene glycol)-lysine copolymer with either cysteamine or 1-amino-2-methyl-2-propanethiol. Cysteine-containing peptides could then be disulfide-linked to the thiol groups on the po