Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Shahram Salek-Ardakani"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Costimulatory receptors on immune cells represent attractive targets for immunotherapy given that these molecules can increase the frequency of individual protective immune cell populations and their longevity, as well as enhance various effector fun
Externí odkaz:
https://doaj.org/article/ddd5a9c0f9684faf8bfc8a9fec372dab
Autor:
Christopher J. Stairiker, Sophia Xiao Pfister, Eleanore Hendrickson, Wenjing Yang, Tao Xie, Catherine Lee, Haikuo Zhang, Christopher Dillon, Graham D. Thomas, Shahram Salek-Ardakani
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Enhancer of Zeste Homolog 2 (EZH2) inhibitors (EZH2i) are approved to treat certain cancer types. Previous studies have suggested the potential to combine EZH2i with immune checkpoint blockade targeting coinhibitory receptors like PD-(L)1 and CTLA-4,
Externí odkaz:
https://doaj.org/article/b009c34667ac4334bd59e24939d35690
Autor:
Shahram Salek-Ardakani, Wenjing Yang, Sheng Ding, Shih-Hsun Chen, Jessica Stanfield, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Javier Chaparro-Riggers, Pawel Dominik, Kevin Lindquist, Thomas Van Blarcom
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1f019c3519b849a08123380e84c26521
Autor:
Shahram Salek-Ardakani, Wenjing Yang, Sheng Ding, Shih-Hsun Chen, Pawel K Dominik, Jessica Stanfield, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Thomas Van Blarcom, Kevin C Lindquist, Javier Chaparro-Riggers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/3920fe53e43c44dd89bb0d4a1c33ff53
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now rev
Externí odkaz:
https://doaj.org/article/bbdfbbdf47a3470dac36776908d741f5
Autor:
Graham Thomas, Luca Micci, Wenjing Yang, Joseph Katakowski, Cecilia Oderup, Purnima Sundar, Xiao Wang, Kenneth G. Geles, Shobha Potluri, Shahram Salek-Ardakani
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Toll-like receptor (TLR) agonists have received considerable attention as therapeutic targets for cancer immunotherapy owing to their ability to convert immunosuppressive tumor microenvironments towards a more T-cell inflamed phenotype. However, TLRs
Externí odkaz:
https://doaj.org/article/f1403811aba84fdf968fa1fa9f033bac
Autor:
Jasmine Davda, Paul Declerck, Siwen Hu-Lieskovan, Timothy P. Hickling, Ira A. Jacobs, Jeffrey Chou, Shahram Salek-Ardakani, Eugenia Kraynov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract The increasing use of multiple immunomodulatory (IMD) agents for cancer therapies (e.g. antibodies targeting immune checkpoints, bispecific antibodies, and chimeric antigen receptor [CAR]-T cells), is raising questions on their potential imm
Externí odkaz:
https://doaj.org/article/c735d9a53cf048839064d6f7f7c085b7
Autor:
S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody bind
Externí odkaz:
https://doaj.org/article/11f466e447544959a4ac278b485a238c
Autor:
Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essentia
Externí odkaz:
https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Tumor-associated macrophages (TAMs) are among the main contributors to immune suppression in the tumor microenvironment, however, TAM depletion strategies have yielded little clinical benefit. Here, we discuss the concept that TAMs are also key regul
Externí odkaz:
https://doaj.org/article/e8df3f0b75c0444e925a9b612351bca4