Výsledky vyhledávání - "Shahnaz T. Al Rashid"

Data from Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo

Autor: Robert G. Bristow, David P. Bazett Jones, Kevin M. Prise, Lothar Lilge, David J. Chen, Benjamin P.C. Chen, Yang Xu, Melvyn Folkard, Carla Coackley, Mita Vaid, Farid Jalali, Andrew Cuddihy, Graham Dellaire, Shahnaz T. Al Rashid

Despite a clear link between ataxia-telangiectasia mutated (ATM)–dependent phosphorylation of p53 and cell cycle checkpoint control, the intracellular biology and subcellular localization of p53 phosphoforms during the initial sensing of DNA damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3ad605e53d02b186c5156cf7d4043a
https://doi.org/10.1158/0008-5472.c.6494466.v1

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PP28. THERAPEUTIC COMPOUND DISCOVERY AND VALIDATION OF DRUGS TARGETING A RECURRENT GLIOBLASTOMA (GBM) PHENOTYPE USING LINCS COMPOUNDS VIA QUADRATIC ANALYSES

Autor: Shu-Dong Zhang, Paul G. O’Reilly, Philip D Dunne, Darragh G. McArt, Matthew Alderdice, Kevin M. Prise, Shahnaz T. Al Rashid, Thomas Flannery

Glioblastoma (GBM) is the most prevalent and aggressive of malignant primary brain tumours. Despite multi-modal therapy, including surgical resection, radiotherapy and chemotherapy, GBM continues to be uniformly lethal, with a median survival of 12�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601f9ad64c5e542a7150c46d16f7fc22
https://europepmc.org/articles/PMC5358602/

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Radiation microbeams as spatial and temporal probes of subcellular and tissue response

Autor: Kevin M. Prise, Giuseppe Schettino, Shahnaz T. Al Rashid

Publikováno v: Mutation Research/Reviews in Mutation Research. 704:68-77

Understanding the effects of ionising radiations are key to determining their optimal use in therapy and assessing risks from exposure. The development of microbeams where radiations can be delivered in a highly temporal and spatially constrained man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155583aca3a3ab2c2f8eda9d3ec9186a
https://doi.org/10.1016/j.mrrev.2010.01.005

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Potential Utility of BimS as a Novel Apoptotic Therapeutic Molecule

Autor: Kenneth W. Yip, Philippe Busson, Jian-Hua Li, Fei-Fei Liu, Wei Shi, Brian O'Sullivan, Shahnaz T. Al Rashid, Ralph W. Gilbert, Marie C. Chia, Joseph D. Mocanu, Anna Li, Alexander V. Louie, Otto Sanchez, Wen-Chen Yeh, Dolly P. Huang, Patrick J. Gullane

Publikováno v: Molecular Therapy. 10(3):533-544

We have previously demonstrated a 1000-fold induction of gene expression exclusive to Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) cells using an adenoviral vector (ad5.oriP). This platform allows us to explore tumor-specific gene

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BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells

Autor: Keeva McClelland, Kai Rothkamm, Kevin M. Prise, Susanne Burdak-Rothkamm, Shahnaz T. Al Rashid

Publikováno v: Burdak-Rothkamm, S, Rothkamm, K, McClelland, K, Al Rashid, S T & Prise, K M 2015, ' BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells ', Cancer Letters, vol. 356, no. 2 Pt B, pp. 454-61 . https://doi.org/10.1016/j.canlet.2014.09.043

Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driv

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https://pubmed.ncbi.nlm.nih.gov/25304378

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Identification of Campylobacter jejuni , C. coli , C. lari , C. upsaliensis , Arcobacter butzleri , and A. butzleri -Like Species Based on the glyA Gene

Autor: Shahnaz T. Al Rashid, Voon Loong Chan, Wendy M. Johnson, David Ng, Irene Dakuna, Helena Louie, Peter Vandamme

Publikováno v: Journal of Clinical Microbiology. 38:1488-1494

Currently, the detection and identification of Campylobacter and Arcobacter species remains arduous, largely due to cross-species phenotypic similarities and a relatively narrow spectrum of biochemical reactivity. We have developed a PCR-hybridizatio

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https://doi.org/10.1128/jcm.38.4.1488-1494.2000

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Characterization of Campylobacter upsaliensis fur and its localization in a highly conserved region of the Campylobacter genome

Autor: Voon Loong Chan, Shahnaz T. Al Rashid, Billy Bourke, Hermine L. Bingham

Publikováno v: Gene. 183:219-224

Despite increasing recognition of the importance of Campylobacter upsaliensis in human disease little is known about either the virulence properties or genetics of this enteric pathogen. The complete coding sequence of a C. upsaliensis gene has yet t

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https://doi.org/10.1016/s0378-1119(96)00562-8

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Abstract 72: Therapeutic compound discovery targeting a recurrent glioblastoma (GBM) phenotype using LINCS compounds via QUADrATiC analyses

Autor: Shahnaz T. Al Rashid, Shu-Dong Zhang, Thomas Flannery, Philip D Dunne, Darragh G. McArt, Matthew Alderdice, Kevin M. Prise, Paul G. O’Reilly

Publikováno v: Cancer Research. 76:72-72

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bbfe11bb1c74fc041c8ea0256ec74c2
https://doi.org/10.1158/1538-7445.am2016-72

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