Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shahnaz P. Yusaf"'
Autor:
Christopher D. Benham, Catherine H. Gill, Shahnaz P. Yusaf, Andrew D. Randall, Paul J. L. M. Strijbos, Andrew J. Powell, Ceri H. Davies, Davina E. Owen, William Cairns, Kerstin Hill, Phil M Larkman, Paul R. Murdock, Stewart Bates
Publikováno v:
British Journal of Pharmacology. 143:411-421
Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0705945 [Full text of this article is not available in the UHRA]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e140d807961cdcd0510a2c4d220b5ca
https://doi.org/10.1038/sj.bjp.0705945
https://doi.org/10.1038/sj.bjp.0705945
Autor:
Alistair K. Dixon, Kevin Lee, Shahnaz P. Yusaf, R. D. Pinnock, James Goodman, Steven Bramwell, Isabel M. Gonzalez
Publikováno v:
Biochemical and Biophysical Research Communications. 289:402-406
Voltage-gated calcium channels (VGCCs) within sensory neurones are believed to perform an important role in neuropathic pain. In the present study we examine the changes in VGCC mRNA which occur following streptozocin- (STZ) induced diabetic neuropat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646a0f04d311e2739b5cd1b8620e007a
https://doi.org/10.1006/bbrc.2001.5943
https://doi.org/10.1006/bbrc.2001.5943
Publikováno v:
The Journal of Physiology. 521:315-326
1. The gating properties of voltage-gated potassium channels are largely determined by the amino acid sequence of their S4 segments. To investigate the nature of S4 movement during gating, we introduced single cysteines into the S4 segment of the Sha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903fdae34a944960eda83b15ab32ee26
https://doi.org/10.1111/j.1469-7793.1999.00315.x
https://doi.org/10.1111/j.1469-7793.1999.00315.x
Autor:
Elisa Ballini, Benjamin D. Bax, Beatrice Oliosi, Claudette Mookherjee, Daniel Marcus Bradley, Stuart P. Ballantine, Nigel E. Austin, Kevin M. Thewlis, Rosemary A. Melarange, Shahnaz P. Yusaf, Gianni Dal Negro, Andrew Jonathan Harris, J. Mosley, Kathrine J. Smith, Laura Aldegheri, Simon E. Ward, B. Clarke, Stephen A Harrison, Mark H Harries, Patrick M. Woollard
Publikováno v:
Journal of medicinal chemistry. 54(1)
A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f968ae85bfba5e74967880d1ee4d863
https://pubmed.ncbi.nlm.nih.gov/21128618
https://pubmed.ncbi.nlm.nih.gov/21128618
Autor:
Kathrine J. Smith, Roberto Profeta, Simon E. Ward, Marta Neve, Simone Spada, Beatrice Oliosi, Jesper Lund, Andrew Jonathan Harris, Anna Mingardi, Claudette Mookherjee, Stuart P. Ballantine, Rosemary A. Melarange, Laura Aldegheri, Andy J. Harker, Benjamin D. Bax, Mark H Harries, Kevin M. Thewlis, Paul W. Smith, Daniele Andreotti, J. Mosley, Shahnaz P. Yusaf
Publikováno v:
Journal of medicinal chemistry. 53(15)
A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154b627b7254de36c15c9e847ad6636c
https://pubmed.ncbi.nlm.nih.gov/20614889
https://pubmed.ncbi.nlm.nih.gov/20614889
Publikováno v:
The Journal of biological chemistry. 284(16)
The aim of this work is to study the role of pore residues on drug binding in the NaV1.8 channel. Alanine mutations were made in the S6 segments, chosen on the basis of their roles in other NaV subtypes; whole cell patch clamp recordings were made fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ff24fac0a075d747cc0521e5fa4050
https://pubmed.ncbi.nlm.nih.gov/19233853
https://pubmed.ncbi.nlm.nih.gov/19233853
Autor:
Andrew D. Rhodes, Sundip Modha, Gemma Balmer, Gareth J. Sanger, Han Trinh, Noureddine Zebda, Kim Rance, Rebecca Leyland, Jon P. Spencer, Moore Stephen, Nicola Courtenay, Fiona M. Kelly, Joanna D. Holbrook, Shahnaz P. Yusaf, Martin J. Gunthorpe, Jane Luck, Catherine H. Gill
Publikováno v:
Journal of neurochemistry. 108(2)
The 5-HT(3) receptor is a member of the 'Cys-loop' family of ligand-gated ion channels that mediate fast excitatory and inhibitory transmission in the nervous system. Current evidence points towards native 5-HT(3) receptors originating from homomeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b928c227707f177c07524396786364
https://pubmed.ncbi.nlm.nih.gov/19012743
https://pubmed.ncbi.nlm.nih.gov/19012743
Autor:
Catherine H, Gill, Andrew, Randall, Stewart A, Bates, Kerstin, Hill, Davina, Owen, Phil M, Larkman, William, Cairns, Shahnaz P, Yusaf, Paul R, Murdock, Paul J L M, Strijbos, Andrew J, Powell, Christopher D, Benham, Ceri H, Davies
Publikováno v:
British journal of pharmacology. 143(3)
The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. Activation of this recombinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::339ddbab40ea983a5dbaff0fa8cf3ec4
https://pubmed.ncbi.nlm.nih.gov/15351778
https://pubmed.ncbi.nlm.nih.gov/15351778
Autor:
Myeong-H Wang, Alison Grainge, Shahnaz P. Yusaf, Atul Mohindra, Asipu Sivaprasadarao, Tim S. Munsey, Dennis Wray
Publikováno v:
Biochemical and biophysical research communications. 297(1)
To test the hypothesis that the Kch gene of Escherichia coli encodes a potassium channel, we have transformed E. coli with an expression vector containing the Kch sequence and observed the effect of over-expression of Kch on E. coli. We found that: (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b1ca8c7d2360ebbb0df8eec9ccd8b9
https://pubmed.ncbi.nlm.nih.gov/12220501
https://pubmed.ncbi.nlm.nih.gov/12220501
Publikováno v:
Neuroscience letters. 311(2)
In the present study, we have used in situ hybridisation to examine the distribution of calcium channel subunits in rat dorsal root ganglion (DRG) neurons. Within DRG neurons, the calcium channel alpha subunit mRNAs alpha(1A), alpha(1B), alpha(1C), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371437a3c60427fc10d956b45d6c53bd
https://pubmed.ncbi.nlm.nih.gov/11567797
https://pubmed.ncbi.nlm.nih.gov/11567797