A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.

Autor: Chamoli M; Buck Institute for Research on Aging, Novato, CA, USA. mchamoli@buckinstitute.org., Rane A; Buck Institute for Research on Aging, Novato, CA, USA., Foulger A; Buck Institute for Research on Aging, Novato, CA, USA., Chinta SJ; Buck Institute for Research on Aging, Novato, CA, USA.; Touro University California, Vallejo, CA, USA., Shahmirzadi AA; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Kumsta C; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Nambiar DK; Stanford University, Stanford, CA, USA., Hall D; Buck Institute for Research on Aging, Novato, CA, USA., Holcom A; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Angeli S; Buck Institute for Research on Aging, Novato, CA, USA., Schmidt M; Buck Institute for Research on Aging, Novato, CA, USA.; University of Southern California, Los Angeles, CA, USA., Pitteri S; Stanford University, Stanford, CA, USA., Hansen M; Buck Institute for Research on Aging, Novato, CA, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA, USA. glithgow@buckinstitute.org., Andersen JK; Buck Institute for Research on Aging, Novato, CA, USA. jkandersen@buckinstitute.org.

Publikováno v: Nature aging [Nat Aging] 2023 Dec; Vol. 3 (12), pp. 1529-1543. Date of Electronic Publication: 2023 Nov 13.