Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shahin Assefnia"'
Autor:
Louis M. Weiner, Bedilu Allo, Michael J. Pishvaian, Sara C. Sprague, Ivana Peran, Shahin Assefnia, Stephen S. Yoo, Eveline E. Vietsch, Michael B. Atkins, Kelly A. Martin, Anton Wellstein, Andrew A. Quong, Aimy Sebastian, Nicholas R. Hum, Gabriela G. Loots, Matthew McCoy, Stephen W. Byers, Sivanesan Dakshanamurthy, Anastasia Mavropoulos
Publikováno v:
Gastroenterology
Gastroenterology, vol 160, iss 4
Gastroenterology, vol 160, iss 4
BACKGROUND & AIMS: Pancreatic ductal adenocarcinomas (PDAC) are characterized by fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated strategies to disrupt interactions among CAFs, the immune system, and cancer cells, fo
Autor:
Deborah W. Neklason, Stephen W. Byers, Thérèse M Tuohy, Jaeil Ahn, Paul J Bueno De Mesquita, Shahin Assefnia, Randall W. Burt, Yong-Sik Bong
Publikováno v:
Oncotarget, vol 7, iss 49
Oncotarget
Oncotarget
// Yong-Sik Bong 1, * , Shahin Assefnia 1, * , Therese Tuohy 2 , Deborah W Neklason 2 , Randall W Burt 2 , Jaeil Ahn 3 , Paul J Bueno De Mesquita 1 , Stephen W. Byers 1 1 Georgetown-Lombardi Comprehensive Cancer Center, Department of Oncology, George
Autor:
Zheng Yang, Jenny Zilberberg, Eugenia Dziopa, Christopher J. Kirk, Robert Korngold, Shahin Assefnia, Leah Dziopa, Jennifer Matos
Publikováno v:
Biology of Blood and Marrow Transplantation. 21:1555-1564
In the current study we evaluated the effects of immunoproteasome inhibition using ONX 0914 (formerly PR-957) to ameliorate graft-versus-host disease (GVHD). ONX 0914, an LMP7-selective epoxyketone inhibitor of the immunoproteasome, has been shown to
Autor:
Keunsoo Kang, Priscilla A. Furth, Ahmad M. Alamri, Shahin Assefnia, Lothar Hennighausen, Svenja Groeneveld, Xuefeng Liu, Daisuke Yamaji, Sarah Dabydeen
Publikováno v:
Endocrine-Related Cancer. 21:443-457
Transformation-related protein 63 (Trp63), the predominant member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia.Trp63features two distinct promoters yielding specific mRNAs encoding two major TRP6
Autor:
Shahin Assefnia, Subha Madhavan, Ashwini Seshasayee, Oakland J. Peters, Naiem T. Issa, Milton L. Brown, Stephen W. Byers, Aykut Üren, Sivanesan Dakshanamurthy
Publikováno v:
Journal of Medicinal Chemistry. 55:6832-6848
The most effective way to move from target identification to the clinic is to identify already approved drugs with the potential for activating or inhibiting unintended targets (repurposing or repositioning). This is usually achieved by high throughp
Publikováno v:
The FASEB Journal. 21
Autor:
Milton L. Brown, Aykut Üren, Bhaskar Kallakury, Sivanesan Dakshanamurthy, Lawrence Shapiro, Constanze Hampel, David W. Foley, Panos Z. Anastasiadis, Michael B. Brenner, Shahin Assefnia, Stephen W. Byers, David Haigh, Jaime M. Guidry Auvil
Publikováno v:
Molecular Cancer Research. 11:A045-A045
Rational: Poor prognosis epithelial-derived cancers often exhibit morphologic and molecular changes characteristic of an epithelial to mesenchymal transition (EMT). EMT markers are predominantly found in tumors with a basal-like phenotype. Increased
Autor:
Shahin Assefnia, Priscilla A. Furth
Publikováno v:
Biology of Reproduction. 78:213-214
Publikováno v:
Cancer Prevention Research. 1:B71-B71
B71 Rational Loss of full length Brca1 in mammary epithelial cells of conditional knockout mice is associated with an aberrant proliferative response to estrogen treatment promoting cancer progression. We had previously found that loss of full-length
Autor:
Juan P. Palazzo, John Quackenbush, Karen E. Rasmussen, Yuzhi Yin, Subhashini Chandrasekharan, Levy Kopelovich, Zhiyuan Hu, Gary A. Churchill, Andrey Khramtsov, Jeffrey E. Green, Charles M. Perou, Jason I. Herschkowitz, Olufunmilayo I. Olopade, Laundette P. Jones, Powel H. Brown, Victor J. Weigman, Igor Mikaelian, Michael G. Backlund, Philip S. Bernard, Priscilla A. Furth, Roy Bastein, Robert I. Glazer, Karl Simin, Jerry Usary, Terry Van Dyke, Shahin Assefnia
Publikováno v:
Genome biology, vol 8, iss 5
Genome Biology
Genome Biology
Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human subtypes were conserved among mouse models.
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