Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Shahin, Lockman"'
Autor:
Dorcas Maruapula, Doreen Ditshwanelo, Marea N. Pema, Ontlametse T. Bareng, Wonderful T. Choga, Natasha O. Moraka, Patrick T. Mokgethi, Kaelo K. Seatla, Catherine K. Koofhethile, Boitumelo J. Zuze, Tendani Gaolathe, Molly Pretorius-Holme, Kebaneilwe Lebani, Joseph Makhema, Vlad Novitsky, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundWe evaluated the prevalence of archived proviral drug resistance mutations (DRMs) associated with resistance to integrase strand transfer inhibitors (INSTIs) shortly before Botswana transitioned in 2016 to using dolutegravir (DTG)-based ant
Externí odkaz:
https://doaj.org/article/38caff23dfd94972b28750adba2eaf3b
Autor:
Mosepele Mosepele, Ponego Ponatshego, Kesaobaka Molebatsi, Christopher Williams, Lucky Mokgatlhe, Shahin Lockman, Nabila Youssouf, Robert Gross, Joseph Jarvis, Duolao Wang, Shabbar Jaffar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract Chronic HIV disease is associated with a fivefold increase in albuminuria outside of sub-Saharan Africa. However, very little is known about albuminuria risk among people living with HIV (PLWH) in sub-Saharan Africa. Therefore, we conducted
Externí odkaz:
https://doaj.org/article/ab88df1c66294dc99e510c62bb6a57f6
Autor:
Onkabetse Julia Molefe-Baikai, Kago Kebotsamang, Pinkie Modisawakgomo, John Thato Tlhakanelo, Keneilwe Motlhatlhedi, Thato Moshomo, Nabila Farah Youssouf, Tiny Masupe, Tendani Gaolathe, Neo Tapela, Shahin Lockman, Mosepele Mosepele
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Morbidity and mortality due to cardiovascular diseases (CVDs) are high and increasing in low- and middle-income countries. People living with HIV (PLWH) are more likely to experience CVD than members of the general population. The
Externí odkaz:
https://doaj.org/article/089997654df948319cd6a52fc569222f
Autor:
Wonderful T. Choga, Gobuiwang Khilly Kurusa (Gasenna), James Emmanuel San, Tidimalo Ookame, Irene Gobe, Mohammed Chand, Badisa Phafane, Kedumetse Seru, Patience Matshosi, Boitumelo Zuze, Nokuthula Ndlovu, Teko Matsuru, Dorcas Maruapula, Ontlametse T. Bareng, Kutlo Macheke, Lesego Kuate-Lere, Labapotswe Tlale, Onalethata Lesetedi, Modiri Tau, Mpaphi B. Mbulawa, Pamela Smith-Lawrence, Mogomotsi Matshaba, Roger Shapiro, Joseph Makhema, Darren P. Martin, Tulio de Oliveira, Richard J. Lessells, Shahin Lockman, Simani Gaseitsiwe, Sikhulile Moyo
Publikováno v:
International Journal of Infectious Diseases, Vol 138, Iss , Pp 91-96 (2024)
We investigated intra-host genetic evolution using two SARS-CoV-2 isolates from a fully vaccinated (primary schedule x2 doses of AstraZeneca plus a booster of Pfizer), >70-year-old woman with a history of lymphoma and hypertension who presented a SAR
Externí odkaz:
https://doaj.org/article/a4563b67ede2463ca061c016f76e974e
Autor:
Kabo Baruti, Wonderful T. Choga, Patience C. Motshosi, Bonolo B. Phinius, Basetsana Phakedi, Lynnette N. Bhebhe, Gorata G. A. Mpebe, Chanana D. Tsayang, Tsholofelo Ratsoma, Tendani Gaolathe, Mosepele Mosepele, Joseph Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Mosimanegape Jongman, Motswedi Anderson, Simani Gaseitsiwe
Publikováno v:
Viruses, Vol 16, Iss 10, p 1568 (2024)
Hepatitis delta virus (HDV) co-infections more often result in severe hepatitis compared to hepatitis B virus (HBV) infections alone. Despite a high HDV prevalence (7.1%), information regarding circulating HDV clades is very limited in Botswana. We e
Externí odkaz:
https://doaj.org/article/2d6198167f544ac78b046379bd6afd2a
Autor:
Kabo Baruti, Bonolo B. Phinius, Basetsana Phakedi, Gorata Mpebe, Wonderful Choga, Lynnette Bhebhe, Graceful Mulenga, Natasha O. Moraka, Tsholofelo Ratsoma, Molly Pretorius-Holme, Joseph Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Mosimanegape Jongman, Motswedi Anderson, Simani Gaseitsiwe
Publikováno v:
Journal of Infection and Public Health, Vol 16, Iss 11, Pp 1736-1741 (2023)
Background: Approximately 15–20 million people worldwide are infected with hepatitis delta virus (HDV), which is approximately 5 % of people with chronic hepatitis B virus (HBV). Sub-Saharan Africa has high HDV prevalence, leading to worse clinical
Externí odkaz:
https://doaj.org/article/dd66fdf5db2c49a28d573a6c8fee0b9e
Autor:
Natasha O. Moraka, Wonderful T. Choga, Marea N. Pema, Moses Kudzai Chawawa, Irene Gobe, Margaret Mokomane, Ontlametse T. Bareng, Lynette Bhebhe, Nametso Kelentse, Graceful Mulenga, Molly Pretorius Holme, Terence Mohammed, Catherine K. Koofhethile, Joseph M. Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We used HIV-1C sequences to predict (in silico) resistance to 33 known broadly neutralizing antibodies (bnAbs) and evaluate the different HIV-1 Env characteristics that may affect virus neutralization. We analyzed proviral sequences from adu
Externí odkaz:
https://doaj.org/article/34cd02c202c244d98df4161bb39f3c8a
Autor:
Mosepele Mosepele, Kara Bennett, Tendani Gaolathe, Joseph M. Makhema, Mompati Mmalane, Molly Pretorius Holme, Refeletswe Lebelonyane, Omolola Ometoruwa, Lisa A. Mills, Kathleen M. Powis, Jean Leidner, Joseph N. Jarvis, Neo M. Tapela, Tiny Masupe, Lucky Mokgatlhe, Virginia A. Triant, Kathleen E. Wirth, Thato Moshomo, Shahin Lockman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract In a population-based representative sample of adults residing in 22 communities in Botswana, a southern African country with high HIV prevalence, 1 in 4 individuals had high blood pressure. High blood pressure was less prevalent in adults w
Externí odkaz:
https://doaj.org/article/174ff52153ae468a92b25f628227a934
Autor:
Bonolo B. Phinius, Wonderful T. Choga, Motswedi Anderson, Margaret Mokomane, Irene Gobe, Tsholofelo Ratsoma, Basetsana Phakedi, Gorata Mpebe, Lynnette Bhebhe, Tendani Gaolathe, Mosepele Mosepele, Joseph Makhema, Roger Shapiro, Shahin Lockman, Rosemary Musonda, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1561 (2024)
(1) Background: Hepatitis B virus (HBV) sequencing data are important for monitoring HBV evolution. We aimed to molecularly characterize HBV sequences from participants with HBV surface antigen-positive (HBsAg+) serology and occult hepatitis B infect
Externí odkaz:
https://doaj.org/article/6829cfe2e45447ae99c2e3fcd79459a4
Autor:
Wonderful T. Choga, Samantha L. Letsholo, Chandapiwa Marobela‐Raborokgwe, Irene Gobe, Mbatshi Mazwiduma, Dorcas Maruapula, John Rukwava, Mary Gorettie Binta, Boitumelo J. L Zuze, Legodile Koopile, Kedumetse Seru, Patience Motshosi, Ontlametse Thato Bareng, Botshelo Radibe, Pamela Smith‐Lawrence, Kutlo Macheke, Lesego Kuate‐Lere, Modisa S. Motswaledi, Mpaphi B. Mbulawa, Mogomotsi Matshaba, Kereng V. Masupu, Shahin Lockman, Roger Shapiro, Joseph Makhema, Mosepele Mosepele, Simani Gaseitsiwe, Sikhulile Moyo
Publikováno v:
Veterinary Medicine and Science, Vol 9, Iss 4, Pp 1465-1472 (2023)
Abstract We sought to investigate whether SARS‐CoV‐2 was present, and to perform full‐length genomic sequencing, in a 5‐year‐old male crossbreed dog from Gaborone, Botswana that presented overt clinical signs (flu‐like symptoms, dry hacki
Externí odkaz:
https://doaj.org/article/92e2601e0fa74b2cb40aab8c50df3dee