MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

Autor: Cazarin J; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., DeRollo RE; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., Shahidan SNABA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., Burchett JB; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., Mwangi D; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., Krishnaiah S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Hsieh AL; The Wistar Institute, Philadelphia, Pennsylvania, United States of America., Walton ZE; The Wistar Institute, Philadelphia, Pennsylvania, United States of America., Brooks R; The Wistar Institute, Philadelphia, Pennsylvania, United States of America., Mello SS; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, United States of America., Weljie AM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Dang CV; Ludwig Institute for Cancer Research, New York, New York, United States of America.; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Maryland, United States of America., Altman BJ; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2023 Aug 28; Vol. 19 (8), pp. e1010904. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023).