Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shahid Tannu"'
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
PDF file - 311KB, Table S1. Results of proliferation assay. Table S2. Estimated PKPD population parameters. Fig. S1. Schematic view of the PK/PD model. Fig S2. Observed PK parameter and model predicted. Fig S3. Visual predictive check.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03937509c03c999ff11b402c64c3a3e1
https://doi.org/10.1158/1078-0432.22456187
https://doi.org/10.1158/1078-0432.22456187
Autor:
Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins
Purpose: Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b1e546610afd48a3c935087a456191
https://doi.org/10.1158/1078-0432.c.6523232.v1
https://doi.org/10.1158/1078-0432.c.6523232.v1
Publikováno v:
Journal of pharmacological and toxicological methods. 106
Introduction Murine transverse aortic constriction (TAC) is a frequently used model of pressure overload-induced left ventricular (LV) remodeling. However, there is considerable variability in disease progression to overt heart failure (HF) developme
Autor:
Michael Linn, Sazzad Hussain, Zoran Filipovic, Packman Kathryn E, Christophe Meille, Edmund J.D. Lee, Kenneth Kolinsky, David C. Heimbrook, Antje Walz, Lyubomir T. Vassilev, Brian Higgins, Rosario Garrido, Violeta Adames, Kelli Glenn, Christian Tovar, Shahid Tannu
Publikováno v:
Clinical Cancer Research. 20:3742-3752
Purpose: Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we
Autor:
Shaoqing Chen, Paul Gillespie, Sung-Sau So, Steven Gregory Mischke, David Robert Bolin, Nam T. Le, Frank Mennona, Mushtaq Ahmad, Karin Conde-Knape, Charles Burghardt, Hong Wang, Shahid Tannu, Yimin Qian, Jarema Peter Kochan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6264-6269
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this cla
Publikováno v:
Journal of Cardiac Failure. 24:S27
Autor:
J Paciorek, Bolin, Jessica D. Ventre, P Gardiner, D Lavelle, L Calzetta, Shahid Tannu, Alexandra Hicks, Nadine Tare, Maureen Hargaden, A Morschauser, Laura Singer, Ta Lin, ID Knowles, M Cazzola, H Michel, Maria Gabriella Matera, Louis M. Renzetti
Publikováno v:
British Journal of Pharmacology. 161:1329-1342
BACKGROUND AND PURPOSE Vasoactive intestinal peptide is expressed in the respiratory tract and induces its effects via its receptors, VPAC1 and VPAC2. RO5024118 is a selective VPAC2 receptor agonist derived via chemical modification of an earlier VPA
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago
Autor:
Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
Publikováno v:
Journal of medicinal chemistry. 56(20)
The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to three BIR domains that are crucial for their inhibitory function. The pro-survival properties of XIAP come from binding of
Autor:
Xiuying Ma, John Allocco, Pancras C. Wong, Earl J. Crain, William A. Schumacher, Shahid Tannu, Dike Qiu, Patricia L. Smith, Xue-Qing Chen, Brian J. Arey, Jeffrey S. Bostwick, Marisa Flaim
Publikováno v:
Journal of Cardiac Failure. 22:S37