Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shahid Rehan"'
Autor:
Shahid Rehan, Dale Tranter, Phillip P. Sharp, Eric Lowe, Janet L. Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Gregory B. Craven, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matt Jacobson, Dustin McMinn, Christopher J. Kirk, Juha T. Huiskonen, Jack Taunton, Ville O. Paavilainen
Publikováno v:
Nature Chemical Biology.
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we describe KZR-8445, a cyclic depsipeptide that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d80e4c56784d2bb4cb97a4236159d8
https://doi.org/10.1038/s41589-023-01326-1
https://doi.org/10.1038/s41589-023-01326-1
Autor:
Wukun Liu, Sam Y. Hong, Zhaoli Sun, Brett R. Ullman, Jingxin Wang, Zlatina Tarmakova, Shridhar Bhat, Zufeng Guo, Ville O. Paavilainen, Manisha Das, Brandon J. Peiffer, Wei Li, Shahid Rehan, Imogen R. Coe, Cordelia Schiene-Fischer, Hanjing Peng, Gunter Fischer, Jun O. Liu, Chung Ming Tse
Publikováno v:
Nature chemistry
Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action—they form binary complexes with FKBP through a shared FKBP-binding domain before forming ternary complexes with their respective targets, mTOR and calcineurin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115b2634250a45b22adaa3931b6274f0
https://doi.org/10.32920/21979724
https://doi.org/10.32920/21979724
Autor:
Sudeep Karki, Dale Tranter, Juha Huiskonen, Matti Javanainen, Shahid Rehan, Lotta Happonen, Ville Paavilainen
Protein translocation across the endoplasmic reticulum (ER) membrane is an essential initial step in protein entry into the secretory pathway. The conserved Sec61 protein translocon facilitates polypeptide translocation and coordinates cotranslationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c671852238d0963702ffd0c46076ef6c
https://doi.org/10.1101/2022.09.30.510141
https://doi.org/10.1101/2022.09.30.510141
Publikováno v:
International Journal of Technology; 2022, Vol. 13 Issue 6, p1271-1281, 11p
Autor:
Brian K. Kobilka, Bernadette Byrne, Shahid Rehan, Jonas S. Mortensen, Cristina Cecchetti, Claus J. Loland, Weijiao Huang, Pil Seok Chae, Yang Du, Satoshi Katsube, Ho Jin Lee, Hyoung Eun Bae, Lan Guan
Publikováno v:
Acta Biomaterialia
Acta Biomater
Acta Biomater
Glucoside detergents are successfully used for membrane protein crystallization mainly because of their ability to form small protein-detergent complexes. In a previous study, we introduced glucose neopentyl glycol (GNG) amphiphiles with a branched d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517dccd789eeb33fac3da43e132ed85e
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(10)
Physiological nucleosides are used for the synthesis of DNA, RNA, and ATP in the cell and serve as universal mammalian signaling molecules that regulate physiological processes such as vasodilation and platelet aggregation by engaging with cell surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b09076f62e68668b29e33530fb5b65c
https://pubmed.ncbi.nlm.nih.gov/31503511
https://pubmed.ncbi.nlm.nih.gov/31503511
Publikováno v:
Biochemical Pharmacology. 98:681-689
Many nucleoside transport inhibitors are in clinical use as anti-cancer, vasodilator and cardioprotective drugs. However, little is known about the binding energetics of these inhibitors to nucleoside transporters (NTs) due to their low endogenous ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e250300b772a946f29aa3e1586ad9c3c
https://doi.org/10.1016/j.bcp.2015.09.019
https://doi.org/10.1016/j.bcp.2015.09.019
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1859(5)
The human equilibrative nucleoside transporter-1 (hENT1) is important for the entry of anti-cancer and antiviral nucleoside analog therapeutics into the cell, and thus for their efficacy. Understanding of hENT1 structure -function relationship could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2053778454308eb96d1d137e81029402
https://pubmed.ncbi.nlm.nih.gov/28254415
https://pubmed.ncbi.nlm.nih.gov/28254415
Autor:
Veli-Pekka Jaakola, Shahid Rehan
Publikováno v:
Protein expression and purification. 114
Human equilibrative nucleoside transporter-1 (hENT1) is the major plasma membrane transporter involved in transportation of natural nucleosides as well as nucleoside analog drugs, used in anti-cancer and anti-viral therapies. Despite extensive bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765e337a5e63d751e3501a89a08efe83
https://pubmed.ncbi.nlm.nih.gov/26162242
https://pubmed.ncbi.nlm.nih.gov/26162242