Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shahid H Zaman"'
Autor:
Madeleine J. Walpert, Eduardo M. Normando, Tiina Annus, Sally R. Jennings, Liam R. Wilson, Peter Watson, Shahid H. Zaman, M. Francesca Cordeiro, Anthony J. Holland
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 744-751 (2019)
Abstract Introduction People with Down's syndrome (DS) have a high prevalence of early‐onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treat
Externí odkaz:
https://doaj.org/article/0d77ee63dfbc49e0b739603468bb2142
Autor:
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J. Walpert, Tiina Annus, Liam R. Wilson, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin I. Aigbirhio, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, David K. Menon, Peter J. Nestor, Shahid H. Zaman, Anthony J. Holland
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 654-658 (2019)
Abstract Introduction Comorbid Alzheimer disease pathologies are frequently found in people with Down syndrome (DS). We report a deep phenotyping study undertaken over 7 years in a participant with DS who was nondemented at baseline but developed dem
Externí odkaz:
https://doaj.org/article/cf9f58123da64fa0b0dfa7a35446bd59
Autor:
Jessica A. Beresford-Webb, Elijah Mak, Monika Grigorova, Samuel J. Daffern, Anthony J. Holland, Shahid H. Zaman
Publikováno v:
BJPsych Open, Vol 7 (2021)
Background Diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in people with Down syndrome is a major challenge. The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual
Externí odkaz:
https://doaj.org/article/93e23a6d682f451297d45ec6c5e8aa04
Autor:
Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P. Friedland, Anthony Holland, Shahid H. Zaman, Elizabeta B. Mukaetova-Ladinska, Ruma Raha-Chowdhury
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an iron storage protein is o
Externí odkaz:
https://doaj.org/article/1f78d9233c494996bc71cc183ea96bca
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage, Vol 228, Iss , Pp 117728- (2021)
Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Du
Externí odkaz:
https://doaj.org/article/f793f64258bb45018fce502f5ace76f4
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102740- (2021)
Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer’s disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary t
Externí odkaz:
https://doaj.org/article/f466772638d948f6b49fdbd04232ca9b
Autor:
Matthew D. Zammit, Charles M. Laymon, Dana L. Tudorascu, Sigan L. Hartley, Brianna Piro‐Gambetti, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, Shahid H. Zaman, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated. Methods Adults with DS (N = 90; mean age [stand
Externí odkaz:
https://doaj.org/article/2a745a8c1cfc4547bf4fcd09aabb4a72
Autor:
Matthew D. Zammit, Charles M. Laymon, Tobey J. Betthauser, Karly A. Cody, Dana L. Tudorascu, Davneet S. Minhas, Marwan N. Sabbagh, Sterling C. Johnson, Shahid H. Zaman, Chester A. Mathis, William E. Klunk, Benjamin L. Handen, Ann D. Cohen, Bradley T. Christian
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load (AβL) was recently developed as an alternative to standardized uptake
Externí odkaz:
https://doaj.org/article/41d1d0c1e3a0429eb5b0708fdaabd6bb
Autor:
Rachel L. Henson, Eric Doran, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, Florence Lai, Joseph H. Lee, H. Diana Rosas, Nicole Schupf, Shahid H. Zaman, Ira T. Lott, Anne M. Fagan
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Virtually all individuals with Down syndrome (DS) will develop Alzheimer's disease (AD) pathology by age 40. Cerebrospinal fluid (CSF) biomarkers have characterized AD pathology in cohorts of late‐onset AD (LOAD) and autosomal
Externí odkaz:
https://doaj.org/article/eefd689289e14cc593bda243f5711e1d
Autor:
Stephanie S.G. Brown, Elijah Mak, Isabel Clare, Monika Grigorova, Jessica Beresford-Webb, Madeline Walpert, Elizabeth Jones, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin I. Aigbirhio, Dana Tudorascu, Annie Cohen, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, David K. Menon, Peter J. Nestor, Anthony J. Holland, Shahid H. Zaman
Publikováno v:
Neurobiology of Aging. 115:112-121
Down's syndrome results from trisomy of chromosome 21, a genetic change which also confers a probable 100% risk for the development of Alzheimer's disease neuropathology (amyloid plaque and neurofibrillary tangle formation) in later life. We aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec8e32921f8b8de884c41e204b82f22
https://doi.org/10.1016/j.neurobiolaging.2022.02.013
https://doi.org/10.1016/j.neurobiolaging.2022.02.013