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Plasma Aβ 42 /Aβ 40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.

Autor: Trelle AN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Young CB; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Vossler H; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Ramos Benitez J; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Cody KA; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Mendiola JH; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Swarovski MS; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Guen YL; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California, USA., Feinstein I; Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California, USA., Butler RR 3rd; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Channappa D; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Romero A; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Park J; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Shahid-Besanti M; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Corso NK; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Chau K; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Smith AN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Skylar-Scott I; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Yutsis MV; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Fredericks CA; Neurology, Yale University, New Haven, Connecticut, USA., Tian L; Biomedical Data Science and Statistics, Stanford University, Stanford, California, USA., Younes K; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Kerchner GA; Pharma Research and Early Development, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Deutsch GK; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Davidzon GA; Radiology, Stanford University, Stanford, California, USA., Sha SJ; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Henderson VW; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Epidemiology & Population Health, Stanford University, Stanford, California, USA., Longo FM; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Greicius MD; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Wyss-Coray T; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Andreasson KI; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Poston KL; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Neurosurgery, Stanford University, Stanford, California, USA., Wagner AD; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Psychology, Stanford University, Stanford, California, USA., Mormino EC; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Wilson EN; Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Dec 23. Date of Electronic Publication: 2024 Dec 23.

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

Autor: Wilson E; Stanford University., Umans J; Stanford University., Swarovski M; Stanford University., Minhas P; Stanford University., Midttun Ø; Bevital., Ulvik AA; Bevital., Shahid-Besanti M; Stanford University., Linortner P; Stanford University., Mhatre S; Stanford University., Wang Q; Stanford University., Channappa D; Stanford University., Corso N; Stanford University., Tian L; Stanford University., Fredericks C; Stanford University., Kerchner G; F. Hoffmann-La Roche, Ltd., Plowey E; Stanford University., Cholerton B; Stanford University., Ueland P; Bevital., Zabetian C; VA Puget Sound Health Care System and University of Washington Seattle., Gray N; Oregon Health & Sciences University., Quinn J; Oregon Health and Sciences University., Montine T; Stanford University., Sha S; Stanford University., Longo F; Stanford University., Wolk D; University of Pennsylvania., Chen-Plotkin A; Perelman School of Medicine at the University of Pennsylvania., Henderson V; Stanford University., Wyss-Coray T; Standford., Wagner A; Stanford University., Mormino E; Stanford University., Aghaeepour N; Stanford University., Poston K; Stanford University., Andreasson K; Stanford University.

Publikováno v: Research square [Res Sq] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.