Predicting Experimental B22 Values and the Effects of Histidine Charge States for Monoclonal Antibodies Using Coarse-Grained Molecular Simulations.

Autor: Shahfar, Hassan, O'Brien, Christopher J., Budyak, Ivan L., Roberts, Christopher J.

Publikováno v: Molecular Pharmaceutics; 11/7/2022, Vol. 19 Issue 11, p3820-3830, 11p

Predicting Experimental B22Values and the Effects of Histidine Charge States for Monoclonal Antibodies Using Coarse-Grained Molecular Simulations

Autor: Shahfar, Hassan, O’Brien, Christopher J., Budyak, Ivan L., Roberts, Christopher J.

Publikováno v: Molecular Pharmaceutics; November 2022, Vol. 19 Issue: 11 p3820-3830, 11p

Predicting Experimental B 22 Values and the Effects of Histidine Charge States for Monoclonal Antibodies Using Coarse-Grained Molecular Simulations.

Autor: Shahfar H; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware19716, United States., O'Brien CJ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware19716, United States., Budyak IL; Bioproduct Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana46285, United States., Roberts CJ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware19716, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2022 Nov 07; Vol. 19 (11), pp. 3820-3830. Date of Electronic Publication: 2022 Oct 04.