Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds

Autor: Rania Helmy Abd-El Hameed, Heba Taha, Samar S. Fatahala, Shahenda Mahgub

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 809-817 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry

Pyrrolopyrimidin-4-ylidene-malononitriles IIa–d were prepared as important intermediates for preparation of a new series of spiro-pyrrolopyrimidines. These intermediates undergo cyclisation via reaction with acetylacetone, guanidine hydrochloride o

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https://doaj.org/article/1fa5bdcd96634a7e88c7fb6834bc8796