Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Shaheer H Khan"'
Autor:
Si Ying Lim, Christopher Hendra, Xin Hao Yeo, Xin Yi Tan, Bao Hui Ng, Anna Karen Carrasco Laserna, Sock Hwee Tan, Mark Y Chan, Shaheer H Khan, Shiaw-Min Chen, Sam Fong Yau Li
Publikováno v:
Glycobiology. 32:469-482
Acute myocardial infarction (AMI) is a leading cause of mortality and morbidity worldwide. Diagnostic challenges remain in this highly time-sensitive condition. Using capillary electrophoresis-laser-induced fluorescence, we analyzed the blood plasma
Autor:
Rosa Viner, Dietmar Reusch, Zoltan Szabo, Philip J. Widdowson, Jonathan Bones, Sara Carillo, Shaheer H. Khan, Andreas Huhmer
Publikováno v:
Analytica Chimica Acta. 1099:155-164
Comparative glycosylation analysis of biopharmaceuticals requires the development of methods that deliver the necessary throughput, support structural elucidation and relative quantitation of glycans released from therapeutics. The current study pres
Autor:
Lulu Wang, Rui Guo, Pingjing Li, Bao Hui Ng, Anna Karen Carrasco Laserna, Shiaw-Min Chen, Ya Ji, Sam Fong Yau Li, Si Ying Lim, Shaheer H. Khan, Huatao Feng
Publikováno v:
Talanta. 239
Recombinant protein biopharmaceuticals comprise a significant portion of the current drug development landscape. The glycosylation profile of these proteins is a key quality parameter as it can affect their safety, efficacy, and stability. However, g
Autor:
Yury Agroskin, Andreas Huhmer, Rosa Viner, Dietmar Reusch, Zoltan Szabo, James R. Thayer, Jeffrey S. Rohrer, Shaheer H. Khan, Christopher A. Pohl, Nebojsa Avdalovic, Sachin Patil, Yan Liu, Michael Krawitzky
Publikováno v:
Journal of Proteome Research. 17:1559-1574
Comprehensive characterization of the N-glycome of a therapeutic is challenging because glycans may harbor numerous modifications (e.g., phosphorylation, sulfation, sialic acids with possible O-acetylation). The current report presents a comparison o
Autor:
Huatao Feng, Pingjing Li, James Stray, Shaheer H. Khan, Shiaw-Min Chen, Guo Rui, Sam Fong Yau Li
Publikováno v:
ELECTROPHORESIS. 38:1788-1799
Analysis of N-glycan structures has been gaining attentions over the years due to their critical importance to biopharma-based applications and growing roles in biological research. Glycan profiling is also critical to the development of biosimilar d
Autor:
Pingjing Li, Michael H. Wenz, Aran Paulus, Shaheer H. Khan, Andreas Krupke, Ya Ji, Daniel Lopez Ferrer, Huatao Feng, Andreas Huhmer, Chien-Hsun Chen, Sam Fong Yau Li, Achim E. Karger, Anna Karen Carrasco Laserna, Shiaw-Min Chen, Rui Guo, Bao Hui Ng
Publikováno v:
Cogent Chemistry, Vol 4, Iss 1 (2018)
Determining and linking the structural heterogeneity of recombinant antibodies to function is critical in the biopharmaceutical industry. We introduce a new microfluidic capillary electrophoresis—mass spectrometry (μCE-MS) approach to characterize
Autor:
Zoltan Szabo, Shaheer H. Khan, Robert J. Linhardt, Yilan Ouyang, Xiaorui Han, Jenkuei Liu, Baburaj Kunnummal, Qiangwei Xia
Publikováno v:
Rapid communications in mass spectrometry : RCM. 32(11)
RATIONALE N-linked glycan analysis of recombinant therapeutic proteins, such as monoclonal antibodies, Fc-fusion proteins, and antibody-drug conjugates, provides valuable information regarding protein therapeutics glycosylation profile. Both qualitat
Autor:
Shaheer H. Khan, Sam Fong Yau Li, James Stray, Pingjing Li, Guo Rui, Shiaw-Min Chen, Huatao Feng
Publikováno v:
ELECTROPHORESIS. 38
Autor:
Kannan Srinivasan, Rosa Viner, Zoltan Szabo, Dietmar Reusch, Julian Saba, Yury Agroskin, Andreas Huhmer, Jeffrey S. Rohrer, James R. Thayer, Rania Harfouche, Shaheer H. Khan, Shanhua Lin, Yan Liu, Christopher A. Pohl
Publikováno v:
Analytical and bioanalytical chemistry. 409(12)
Characterization of glycans present on glycoproteins has become of increasing importance due to their biological implications, such as protein folding, immunogenicity, cell-cell adhesion, clearance, receptor interactions, etc. In this study, the reso
Publikováno v:
Bioconjugate Chemistry. 8:751-756
The syntheses of three novel functionalized tricarbocyanine dyes are described. These dyes containing isothiocyanate and succinimidyl ester functional groups are reactive toward primary amines and can be used as fluorescent probes for biologically pe