Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shaheen Mowla"'
Autor:
Samuel Mawuli Adadey, Edmond Wonkam-Tingang, Leonardo Alves de Souza Rios, Elvis Twumasi Aboagye, Kevin Esoh, Noluthando Manyisa, Carmen De Kock, Gordon A. Awandare, Shaheen Mowla, Ambroise Wonkam
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
We have previously reported CLIC5A and SLC12A2 variants in two families from Cameroon and Ghana, segregating non-syndromic hearing impairment (NSHI). In this study, biological assays were performed to further functionally investigate the pathogenicit
Externí odkaz:
https://doaj.org/article/c30eeef92166471a8d715fdaa6992a3d
Publikováno v:
Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy. Recent evidence s
Externí odkaz:
https://doaj.org/article/8abce41e5411437c9775b7ddab7da816
Autor:
Leonardo Alves de Souza Rios, Lungile Mapekula, Nontlantla Mdletshe, Dharshnee Chetty, Shaheen Mowla
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
HIV-1 infection often leads to the development of co-morbidities including cancer. Burkitt lymphoma (BL) is one of the most over-represented non-Hodgkin lymphoma among HIV-infected individuals, and displays a highly aggressive phenotype in this popul
Externí odkaz:
https://doaj.org/article/50e50651ec27453f9d589361837bb91b
Autor:
Ambroise Wonkam, Kamogelo Lebeko, Shaheen Mowla, Jean Jacques Noubiap, Mike Chong, Guillaume Pare
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Background Hearing impairment (HI) genes are poorly studied in African populations. Methods We used whole exome sequencing (WES) to investigate pathogenic and likely pathogenic (PLP) variants in 10 individuals with HI, from four multiplex fa
Externí odkaz:
https://doaj.org/article/41244a1c9ef84194ac73ebab8f6c64f0
Autor:
Kevin Dzobo, Naseeha Hassen, Dimakatso Alice Senthebane, Nicholas Ekow Thomford, Arielle Rowe, Hendrina Shipanga, Ambroise Wonkam, M. Iqbal Parker, Shaheen Mowla, Collet Dandara
Publikováno v:
Molecules, Vol 23, Iss 4, p 930 (2018)
Background: Environmental pollution such as exposure to pro-carcinogens including benzo-α-pyrene is becoming a major problem globally. Moreover, the effects of benzo-α-pyrene (BaP) on drug pharmacokinetics, pharmacodynamics, and drug resistance war
Externí odkaz:
https://doaj.org/article/3dbbc7e5b7a4454499d7fcc5643a0b17
Autor:
Shaheen Mowla, Riyaadh Ahmed
Publikováno v:
Future Virology. 17:707-710
Autor:
Thashi Bharadwaj, Anushree Acharya, Khurram Liaqat, Gordon A. Awandare, Kevin K Esoh, Elvis Twumasi Aboagye, Shaheen Mowla, Suzanne M. Leal, Sulman Basit, Isabelle Schrauwen, Samuel Mawuli Adadey, Edmond Wonkam-Tingang, Liz M Nouel-Saied, Wasim Ahmad, Ambroise Wonkam
Publikováno v:
Journal of Human Genetics
Congenital hearing impairment (HI) is genetically heterogeneous making its genetic diagnosis challenging. Investigation of novel HI genes and variants will enhance our understanding of the molecular mechanisms and to aid genetic diagnosis. We perform
Publikováno v:
Anticancer Research. 41:237-247
Background/aim Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme which has an essential function in promoting antibody diversification. Its overexpression is strongly associated with B-cell derived malignancies including Burkitt l
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 146:2721-2730
Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and chang
Autor:
Noluthando, Manyisa, Isabelle, Schrauwen, Leonardo Alves, de Souza Rios, Shaheen, Mowla, Cedrik, Tekendo-Ngongang, Kalinka, Popel, Kevin, Esoh, Thashi, Bharadwaj, Liz M, Nouel-Saied, Anushree, Acharya, Abdul, Nasir, Edmond, Wonkam-Tingang, Carmen de, Kock, Collet, Dandara, Suzanne M, Leal, Ambroise, Wonkam
Publikováno v:
Genes
Hearing impairment (HI) is a sensory disorder with a prevalence of 0.0055 live births in South Africa. DNA samples from a South African family presenting with progressive, autosomal dominant non-syndromic HI were subjected to whole-exome sequencing,