Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shaheda Shaikh"'
Autor:
Suresh Babubhai Chahwala, Tenagne Ayele, Chaman Chander, Stuart Buxton, Toby Jonathan Blench, Andrew Burd, Alexandra Watts, Richard Holland, Lihua Zhao, Michael Blackney, Sandrine A. M. Merette, Richard Beck, Shouming Wang, Maja Malic, Shaheda Shaikh
Publikováno v:
Journal of Medicinal Chemistry. 53:1465-1472
FIXa is a serine protease enzyme involved in the intrinsic pathway of the coagulation cascade. The upstream intervention of the coagulation cascade in selectively inhibiting FIXa would leave hemostasis intact via the extrinsic pathway, leading to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f75946cb30138054257618191a17cc9
https://doi.org/10.1021/jm901475e
https://doi.org/10.1021/jm901475e
Autor:
Dana Davis, Sylvie Jezequel, Haiyan Jia, Shaheda Shaikh, David L. Selwood, Marianne Löhr, Ian Zachary
Publikováno v:
Biochemical and Biophysical Research Communications. 283:469-479
Previous findings suggest that both the Tat polypeptide encoded by HIV-1 and Tat-derived peptides can induce angiogenesis via activation of the KDR receptor for Vascular Endothelial Growth Factor (VEGF). We identified 20 amino acids and 12 amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98c1fa6a729ad9f6b62b6279b97c23b
https://doi.org/10.1006/bbrc.2001.4790
https://doi.org/10.1006/bbrc.2001.4790
Autor:
David L. Selwood, Rehan Aqil, Chris Chapman, Ashley Jarvis, Snezana Djordevic, Paul Frankel, A. W. Edith Chan, Basil Hartzoulakis, Haiyan Jia, Shaheda Shaikh, Lili Cheng, John Martin, Antonina Frolov, Ian M. Evans, Ian Zachary
Publikováno v:
Chembiochem : a European journal of chemical biology. 15(8)
The interaction between VEGF-A and its neuropilin (NRP) receptors mediates a number of important biological effects. NRP1 and the related molecule NRP2 are widely expressed on multiple tumour types and throughout the tumour vasculature, and are emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afde498cebb08a6b66b23fd8fed7d74b
https://pubmed.ncbi.nlm.nih.gov/24771685
https://pubmed.ncbi.nlm.nih.gov/24771685
Autor:
Suresh Babubhai Chahwala, Elizabeth Murray, Chaman Chander, Michael Blackney, Stuart Buxton, Toby Jonathan Blench, Andrew Burd, Christine Baumgartner, Chiming Cheung, Amanda Giddings, Tenagne Ayele, Frederic Marlin, Shaheda Shaikh, Mohammed Sajad, Claudio Dagostin, Maja Malic, Hans-Peter Holthoff, John Barry, Richard Beck, Shouming Wang, Rina Joshi
Publikováno v:
Journal of medicinal chemistry. 53(4)
On the basis of our understanding on the binding interactions of the benzothiophene template within the FIXa active site by X-ray crystallography and molecular modeling studies, we developed our SAR strategy by targeting the 4-position of the templat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b68398f7bc5161feafed21edce2072
https://pubmed.ncbi.nlm.nih.gov/20121197
https://pubmed.ncbi.nlm.nih.gov/20121197
Autor:
Basil Hartzoulakis, Ashley Jarvis, Azadeh Bagherzadeh, Lili Cheng, Diego Esposito, Haiyan Jia, Shaheda Shaikh, Paul C. Driscoll, Marianne Löhr, Ian Zachary, Michelle Tickner, David L. Selwood, Richard Harris, Rehan Aqil
Publikováno v:
The Journal of biological chemistry. 281(19)
Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-A165 (VEGF-A165) in endothelial cells. To define the role of NP-1 in the biological functions of VEGF, we developed a specific peptide antagonist of VEGF binding to NP-1 based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737bc2ba5a94f49e460b12887555447d
https://pubmed.ncbi.nlm.nih.gov/16513643
https://pubmed.ncbi.nlm.nih.gov/16513643
Autor:
David L. Selwood, Dana Davis, Haiyan Jia, Sylvie Jezequel, Shay Soker, Shaheda Shaikh, Marianne Löhr, Ian Zachary
Publikováno v:
Biochemical and biophysical research communications. 283(1)
VEGF induces pathological angiogenesis and is an important target for the development of novel antiangiogenic molecules. In this study, we tested synthetic peptides based on the sequence of VEGF(189) for their ability to inhibit VEGF receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d100914ab0f06aa24f6e88ed0004128
https://pubmed.ncbi.nlm.nih.gov/11322784
https://pubmed.ncbi.nlm.nih.gov/11322784