Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shahd Horie"'
Autor:
Matthew Donoghue, Hongchang Wang, Daniel O’Toole, Charles Eugene Connelly, Shahd Horie, Peter Woulfe, Cornelio Salinas, Brid King, Brendan Tuohy, Evan Kiely, Kazimir Wanelik, Kawal Sawhney, Christoph Kleefeld
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The study of biological soft tissue structures at the micron scale details the function of healthy and pathological tissues, which is vital in the diagnosis and treatment of diseases. Speckle based X-ray phase contrast tomographic scans at a
Externí odkaz:
https://doaj.org/article/df7773ea05514526b0ffdb9f2e070f21
Autor:
Declan Byrnes, Claire Masterson, Jack Brady, Shahd Horie, Sean D. McCarthy, Hector Gonzalez, Daniel O’Toole, John Laffey
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionMesenchymal stromal cells (MSC) are a promising therapeutic for pneumonia-induced sepsis. Here we sought to determine the efficacy of delayed administration of naïve and activated bone marrow (BM), adipose (AD), and umbilical cord (UC) d
Externí odkaz:
https://doaj.org/article/81d2bb28fa5c42d3bb405423e7f2cd61
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-19 (2020)
Abstract Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high mortality rate. There are no therapies for sepsis, and it has become a global cause for conc
Externí odkaz:
https://doaj.org/article/f561359a72c24766b943be7d0df060af
Autor:
Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O’Flynn, Steve Elliman, Frank Barry, Timothy O’Brien, John G. Laffey, Daniel O’Toole
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2020)
Abstract Background Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell populations, while bone
Externí odkaz:
https://doaj.org/article/dd72cc88eb7a44899c617e1dd9e90e46
Autor:
Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole, John G. Laffey
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Background Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include restoring hMSC efficacy fo
Externí odkaz:
https://doaj.org/article/a5f6bda4293f4ae6bc17938581e83a10
Autor:
Shahd Horie, Hector Gonzalez, Jack Brady, James Devaney, Michael Scully, Daniel O’Toole, John G. Laffey
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12842 (2021)
Background: Ventilator-induced lung injury (VILI) frequently worsens acute respiratory distress syndrome (ARDS) severity. Human mesenchymal stem/stromal cells (MSCs) offer considerable therapeutic promise, but the key impediments of clinical translat
Externí odkaz:
https://doaj.org/article/c63cc0fb72dc4f1588bf389652937ae7
Autor:
Hector Gonzalez, Colm Keane, Claire H. Masterson, Shahd Horie, Stephen J. Elliman, Brendan D. Higgins, Michael Scully, John G. Laffey, Daniel O’Toole
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8270 (2020)
Mesenchymal stromal cells (MSCs) have a multimodal, immunomodulatory mechanism of action and are now in clinical trials for single organ and systemic sepsis. However, a number of practicalities around source, homogeneity and therapeutic window remain
Externí odkaz:
https://doaj.org/article/1dfd9b618dcc4715acf24571cf168a18
Autor:
Shahd Horie, John G. Laffey
Publikováno v:
F1000Research, Vol 5 (2016)
Acute respiratory distress syndrome (ARDS) causes respiratory failure, which is associated with severe inflammation and lung damage and has a high mortality and for which there is no therapy. Mesenchymal stromal/stem cells (MSCs) are adult multi-prog
Externí odkaz:
https://doaj.org/article/70749801255642f085e068d86f4709bc
Publikováno v:
Current Opinion in Critical Care
Purpose of review Advances in our understanding of the pathophysiology and biology of ARDS has identified a number of promising cellular and pharmacological therapies. These emerging therapeutics can modulate the immune response, reduce epithelial in
Autor:
Claire Masterson, Lisa O'Flynn, Shahd Horie, Steve Elliman, Timothy O'Brien, Paul Loftus, Frank Barry, Emma Horan, Daniel O'Toole, Jack Brady, John G. Laffey
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2020)
Background Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell populations, while bone marrow (B